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Keywords: Cholestatic injury
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Journal Articles
Insulin receptor substrate 2 (IRS2) deficiency delays liver fibrosis associated with cholestatic injury
Open AccessAndrea Villar-Lorenzo, Patricia Rada, Esther Rey, Patricia Marañón, Ana I. Arroba, Beatriz Santamaría, Jorge Sáiz, Francisco J. Rupérez, Coral Barbas, Carmelo García-Monzón, Ángela M. Valverde, Águeda González-Rodríguez
Journal:
Disease Models & Mechanisms
Dis Model Mech (2019) 12 (7): dmm038810.
Published: 16 July 2019
... of insulin and insulin-like growth factor 1 (IGF1) signalling pathways and plays a major role in liver metabolism. The aim of this study was to investigate whether IRS2 had an impact on the hepatic fibrotic process associated with cholestatic injury. Bile duct ligation (BDL) was performed in wild-type (WT...
Includes: Supplementary data
