... an inducible, dominant-negative form of human UPF1 (dnUPF1) to inhibit NMD in mouse tissues by different degrees, allowing us to examine the effects of global NMD inhibition in vivo . A thorough characterization of these mice indicated that expressing dnUPF1 at levels that promote relatively moderate to strong...

..., although their exploratory and anxiety-like behaviours are unaffected. Dopamine D1 receptor Mutant rat Social cognition Characterization Schizophrenia It is now commonly agreed that psychiatric disorders are not fully independent syndromes, but rather represent constellations of symptom...