... and cerebellar nuclei neurons ( Hoffer et al., 1973 ; Schwarz et al., 2015 ). Similarly, the pedunculopontine nucleus, another regulator of REM sleep ( Romigi et al., 2008 ), has both afferent and efferent projections with the cerebellum, and with Purkinje cells in particular ( Mori et al., 2016 ). Hence...

.... Based on the relatively well-preserved cytoarchitecture in the mdx cerebellum, our data suggest that faulty signals across the circuit between Purkinje cells and cerebellar nuclei drive the abnormal firing activity. The in vivo requirements of dystrophin during cerebellar circuit communication could...