.... * These authors contributed equally to this work ‡ Author for correspondence ([email protected]) Handling Editor: Monkol Lek Competing interests B.S.C. and J.L. are co-inventors of a patent on targeting DNM2 for the treatment of centronuclear myopathies, and co-founders of Dynacure...

...Karla G. Espinosa; Salma Geissah; Linda Groom; Jonathan Volpatti; Ian C. Scott; Robert T. Dirksen; Mo Zhao; James J. Dowling ABSTRACT Centronuclear myopathy (CNM) is a congenital neuromuscular disorder caused by pathogenic variation in genes associated with membrane trafficking and excitation...

... remodeling protein mutated in both congenital and adult centronuclear myopathies (CNM), that is ubiquitously expressed and has skeletal muscle-specific isoforms. We created and characterized constitutive muscle-specific and inducible Bin1 homozygous and heterozygous knockout mice targeting either ubiquitous...