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Keywords: Cdk5α
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Journal Articles

Altered expression of the Cdk5 activator-like protein, Cdk5α, causes neurodegeneration, in part by accelerating the rate of aging

Open Access
Joshua Spurrier, Arvind Kumar Shukla, Kristina McLinden, Kory Johnson, Edward Giniger
Journal: Disease Models & Mechanisms
Dis Model Mech (2018) 11 (3): dmm031161.
https://doi.org/10.1242/dmm.031161
Published: 8 March 2018
... by the gene Cdk5α , the ortholog of mammalian p35. Cdk5α -mediated degeneration was associated with a 27-150% acceleration of the intrinsic rate of aging, depending on the tissue and genetic manipulation. Gene ontology analysis and direct experimental tests revealed that affected age-associated processes...
View articletitled, Altered expression of the Cdk5 activator-like protein, Cdk5α, causes neurodegeneration, in part by accelerating the rate of aging
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Includes: Supplementary data