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Keywords: Cardiac remodeling
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Journal Articles
Dis Model Mech (2015) 8 (9): 1081–1091.
Published: 1 September 2015
... is a direct target of miR-146a activity and that downregulation of the Fos–AP-1 pathway by miR-146a has the capacity to inhibit MMP-9 activity. Given that MMP-9 is an AP-1 target gene involved in cardiac remodeling, myocardial dysfunction and progression of heart failure, these findings suggest that miR-146a...
Includes: Supplementary data