...: Using in vitro and in vivo models, this study identifies an important role for CCL2–CCR2 signaling in skeletal muscle wasting associated with breast cancer, with important implications for therapeutic targeting. Breast cancer Cachexia Skeletal muscle wasting Chemokine CCL2...

...Courtney Choutka; Cecilia Cabrera; Susumu Hirabayashi ABSTRACT Cancer continues to be a leading cause of death worldwide, largely due to metastases and cachexia. It is a complex disease that is commonly associated with a variety of comorbidities. With global increases in ageing populations...

...Joshua R. Huot; Leah J. Novinger; Fabrizio Pin; Andrea Bonetto ABSTRACT Colorectal cancer (CRC) is often accompanied by formation of liver metastases (LM) and skeletal muscle wasting, i.e. cachexia. Despite affecting the majority of CRC patients, cachexia remains underserved, understudied...