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Keywords: CX-4945
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Journal Articles
A chemical with proven clinical safety rescues Down-syndrome-related phenotypes in through DYRK1A inhibition
Open AccessHyeongki Kim, Kyu-Sun Lee, Ae-Kyeong Kim, Miri Choi, Kwangman Choi, Mingu Kang, Seung-Wook Chi, Min-Sung Lee, Jeong-Soo Lee, So-Young Lee, Woo-Joo Song, Kweon Yu, Sungchan Cho
Journal:
Disease Models & Mechanisms
Dis Model Mech (2016) 9 (8): 839–848.
Published: 1 August 2016
...-4945, the safety of which has been already proven in the clinical setting, as a potent inhibitor of DYRK1A that acts in an ATP-competitive manner. The inhibitory potency of CX-4945 on DYRK1A (IC 50 =6.8 nM) in vitro was higher than that of harmine, INDY or proINDY, which are well-known potent...
Includes: Supplementary data
