1-6 of 6
Keywords: CRISPR-Cas9
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
Journal Articles
In collection:
Heart Disease
Dis Model Mech (2023) 16 (8): dmm049811.
Published: 16 August 2023
..., functional modeling is a crucial prerequisite for translating genomic data into clinical care. We used CRISPR-Cas9-mediated targeting of 12 candidate genes in the vertebrate model medaka ( Oryzias latipes ), five of which displayed a novel cardiovascular phenotype spectrum in F0 (crispants): mapre2 , smg7...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2022) 15 (3): dmm049161.
Published: 31 March 2022
... toxicity revealed that dopamine treatment protects against the dose-dependent neurotoxicity caused by cisplatin. C. elegans CRISPR-Cas9 Cisplatin Glucose Mitochondria Neurotoxicity Instituto de Salud Carlos III http://dx.doi.org/10.13039/501100004587 PI15/00895 PI18/00920 PI14...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2021) 14 (7): dmm047431.
Published: 23 July 2021
... ( Schmittgen and Livak, 2008 ). Tests for CRISPR-Cas9 gene editing used either previously characterized gRNAs ( Manley, 2019 ) or new gRNAs designed using Integrated DNA Technologies (IDT) custom Alt-R CRISPR-Cas9 guide and MENTHU ( Ata et al., 2018 ) gene-editing software ( Table S2 ). All gRNAs...
Includes: Supplementary data
Journal Articles
Journal Articles
Dis Model Mech (2018) 11 (10): dmm035972.
Published: 18 October 2018
... and zebrafish. Here, we used CRISPR-Cas9 genome editing to directly test whether this Pbx gene variant acts as a genetic modifier in zebrafish heart development. We used a single-stranded oligodeoxynucleotide to precisely introduce the human PBX3 p.A136V variant in the homologous zebrafish pbx4 gene ( pbx4...