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1-6 of 6
Keywords: CRISPR-Cas9
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Journal Articles
Lucie O. M. Perillat, Tatianna W. Y. Wong, Eleonora Maino, Abdalla Ahmed, Ori Scott, Elzbieta Hyatt, Paul Delgado-Olguin, Shagana Visuvanathan, Evgueni A. Ivakine, Ronald D. Cohn
Journal:
Disease Models & Mechanisms
Dis Model Mech dmm.050595.
Published: 5 August 2024
... deletions in the DMD gene that result in the production of a truncated, yet functional, dystrophin protein. The consequences of BMD-causing in-frame deletions on the organism are difficult to predict, especially in regard to long-term prognosis. Here, we employed CRISPR-Cas9 to generate a new Dmd del52-55...
Journal Articles
In collection:
Heart Disease
Lino Doering, Alex Cornean, Thomas Thumberger, Joergen Benjaminsen, Beate Wittbrodt, Tanja Kellner, Omar T. Hammouda, Matthias Gorenflo, Joachim Wittbrodt, Jakob Gierten
Journal:
Disease Models & Mechanisms
Dis Model Mech (2023) 16 (8): dmm049811.
Published: 16 August 2023
..., functional modeling is a crucial prerequisite for translating genomic data into clinical care. We used CRISPR-Cas9-mediated targeting of 12 candidate genes in the vertebrate model medaka ( Oryzias latipes ), five of which displayed a novel cardiovascular phenotype spectrum in F0 (crispants): mapre2 , smg7...
Includes: Supplementary data
Journal Articles
In collection:
C. elegans as a Disease Model
Carmen Martínez-Fernández, Milana Bergamino, Alfonso Schiavi, David Brena, Natascia Ventura, Sebastian Honnen, Alberto Villanueva, Ernest Nadal, Julián Cerón
Journal:
Disease Models & Mechanisms
Dis Model Mech (2022) 15 (3): dmm049161.
Published: 31 March 2022
... toxicity revealed that dopamine treatment protects against the dose-dependent neurotoxicity caused by cisplatin. C. elegans CRISPR-Cas9 Cisplatin Glucose Mitochondria Neurotoxicity Instituto de Salud Carlos III http://dx.doi.org/10.13039/501100004587 PI15/00895 PI18/00920 PI14...
Includes: Supplementary data
Journal Articles
In collection:
Zebrafish as a Disease Model
Abdulsalam I. Isiaku, Zuobing Zhang, Vahid Pazhakh, Harriet R. Manley, Ella R. Thompson, Lucy C. Fox, Satwica Yerneni, Piers Blombery, Graham J. Lieschke
Journal:
Disease Models & Mechanisms
Dis Model Mech (2021) 14 (7): dmm047431.
Published: 23 July 2021
... ( Schmittgen and Livak, 2008 ). Tests for CRISPR-Cas9 gene editing used either previously characterized gRNAs ( Manley, 2019 ) or new gRNAs designed using Integrated DNA Technologies (IDT) custom Alt-R CRISPR-Cas9 guide and MENTHU ( Ata et al., 2018 ) gene-editing software ( Table S2 ). All gRNAs...
Includes: Supplementary data
Journal Articles
Troy A. McDiarmid, Vinci Au, Aaron D. Loewen, Joseph Liang, Kota Mizumoto, Donald G. Moerman, Catharine H. Rankin
Journal:
Disease Models & Mechanisms
Dis Model Mech (2018) 11 (12): dmm036517.
Published: 26 November 2018
... the recent application of whole-exome and whole-genome sequencing has uncovered thousands of genetic variants of uncertain significance. Here, we present a strategy for targeted human gene replacement and phenomic characterization, based on CRISPR-Cas9 genome engineering in the genetic model organism...
Includes: Supplementary data
Journal Articles
In collection:
Zebrafish as a Disease Model
Journal:
Disease Models & Mechanisms
Dis Model Mech (2018) 11 (10): dmm035972.
Published: 18 October 2018
... and zebrafish. Here, we used CRISPR-Cas9 genome editing to directly test whether this Pbx gene variant acts as a genetic modifier in zebrafish heart development. We used a single-stranded oligodeoxynucleotide to precisely introduce the human PBX3 p.A136V variant in the homologous zebrafish pbx4 gene ( pbx4...