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Keywords: CREM/ICER
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Journal Articles
Journal:
Disease Models & Mechanisms
Dis Model Mech (2015) 8 (1): 65–80.
Published: 1 January 2015
... expression of PDE3. Mechanistically, we found that oxidative stress and PKA activation in diabetes enhanced CREM/ICER expression. This reduces IRS2 cellular content by inhibiting cAMP response element (CRE) transcriptional activity. Consequently, a decrease in the activity of Akt-mTOR ensued...
