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Keywords: C3HeB/FeJ
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Journal Articles

Heterogeneous disease progression and treatment response in a C3HeB/FeJ mouse model of tuberculosis

Open Access
Jean-Philippe Lanoix, Anne J. Lenaerts, Eric L. Nuermberger
Journal: Disease Models & Mechanisms
Dis Model Mech (2015) 8 (6): 603–610.
https://doi.org/10.1242/dmm.019513
Published: 1 June 2015
...Jean-Philippe Lanoix; Anne J. Lenaerts; Eric L. Nuermberger ABSTRACT Mice are the most commonly used species for non-clinical evaluations of drug efficacy against tuberculosis (TB). Unlike commonly used strains, C3HeB/FeJ mice develop caseous necrosis in the lung, which might alter...
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Includes: Supplementary data
Journal Articles

Presence of multiple lesion types with vastly different microenvironments in C3HeB/FeJ mice following aerosol infection with Mycobacterium tuberculosis

Open Access
Scott M. Irwin, Emily Driver, Edward Lyon, Christopher Schrupp, Gavin Ryan, Mercedes Gonzalez-Juarrero, Randall J. Basaraba, Eric L. Nuermberger, Anne J. Lenaerts
Journal: Disease Models & Mechanisms
Dis Model Mech (2015) 8 (6): 591–602.
https://doi.org/10.1242/dmm.019570
Published: 1 June 2015
... to screen and evaluate novel tuberculosis drugs and drug regimens. Pulmonary disease in humans is characterized by a number of heterogeneous lesion types that reflect differences in cellular composition and organization, extent of encapsulation, and degree of caseous necrosis. C3HeB/FeJ mice have been...
View articletitled, Presence of multiple lesion types with vastly different microenvironments in C3HeB/FeJ mice following aerosol infection with Mycobacterium tuberculosis
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