... conservation and experimental tractability. Here, a paradigm enabling C. elegans qHTS using 384-well microtiter plate laser-scanning cytometry is described, in which GFP-expressing organisms revealing phenotype-modifying structure–activity relationships guide subsequent life-stage and proteomic analyses...

... elegans strains that recreated patient-specific point variants in the C. elegans ortholog ( nfu-1 ) that result in allele-specific dysfunction. Each of these mutants, Gly147Arg and Gly166Cys, have altered acetylcholine signaling at neuromuscular junctions, but opposite effects on activity and motility. We...

... Caenorhabditis elegans to identify genetic factors influencing the sensitivity and resistance to cisplatin. In this study, we used C. elegans to explore cisplatin effects on mitochondrial functions and investigate cisplatin-induced neurotoxicity through a high-resolution system for evaluating locomotion. First...

... Attribution License ( https://creativecommons.org/licenses/by/4.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Fig. 1. Age-dependent defects in structural organization of the C. elegans body wall muscle...

... the small model organisms that excel in rare disease modeling is the nematode Caenorhabditis elegans . With a staggering breadth of research tools, C. elegans provides an ideal system in which to study human disease. Molecular and cellular processes can be easily elucidated, assayed and altered in ways...

... Comprehensive metabolomic and lipidomic mass spectrometry methods are in increasing demand; for instance, in research related to nutrition and aging. The nematode Caenorhabditis elegans is a key model organism in these fields, owing to the large repository of available C. elegans mutants and their convenient...

... homozygous for P74S. The P74S and G155S alleles also reveal evidence of a very close functional association between the B9D2-associated B9 complex and MKS-2/TMEM216. Together, these data establish C. elegans as a model for interpreting JBTS mutations and provide further insight into MKS module organisation...

... ( Senoo-Matsuda et al., 2001 ). However, little is known about worm SDHB. The C. elegans succinate dehydrogenase B homolog sdhb-1 gene was first analyzed by Huang and Lemire (2009) , who found a well-conserved proline residue close to the proximal quinone-binding site (Qp). When this Pro211...

..., independent of Aβ, exerted no impact on survival. Taken together, these results illustrate that C. elegans provides a powerful in vivo platform with which to explore how AD-associated neuronal pathways are modulated by distinct APOE gene products in the context of Aβ-associated neurotoxicity. The significance...

... of muscular strength in dystrophin-deficient C. elegans mutants using a micropillar-based force measurement system called NemaFlex . We show that dys-1(eg33) mutants, but not dys-1(cx18) mutants, are significantly weaker than their wild-type counterparts in early adulthood, cannot thrash in liquid at wild...

... to focus on application rather than discovery ( Fang and Casadevall, 2010 ; Hand et al., 2013 ; Minogue and Wolinsky, 2010 ). It is therefore with a sense of urgency that we write this article to defend the winning strategy of ‘discovery first’. C. elegans Drosophila Invertebrates Sea...

... neurodegeneration in mouse models of familial amyotrophic lateral sclerosis . J. Neurosci.   28 , 13574 - 13581 . 10.1523/JNEUROSCI.4099-08.2008 Veriepe , J. , Fossouo , L. and Parker , J. A. ( 2015 ). Neurodegeneration in C. elegans models of ALS requires TIR-1/Sarm1 immune pathway...