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Keywords: Brain energy metabolism
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Journal Articles

Ammonia inhibits energy metabolism in astrocytes in a rapid and glutamate dehydrogenase 2-dependent manner

Open Access
Leonie Drews, Marcel Zimmermann, Philipp Westhoff, Dominik Brilhaus, Rebecca E. Poss, Laura Bergmann, Constanze Wiek, Peter Brenneisen, Roland P. Piekorz, Tabea Mettler-Altmann, Andreas P. M. Weber, Andreas S. Reichert
Journal: Disease Models & Mechanisms
Dis Model Mech (2020) 13 (10): dmm047134.
https://doi.org/10.1242/dmm.047134
Published: 4 November 2020
... dehydrogenase 2 impairs energy metabolism in mitochondria very rapidly via inhibiting the TCA cycle in astrocytes. Hepatic encephalopathy Hyperammonemia Mitochondria TCA cycle Glutamate dehydrogenase Brain energy metabolism Deutsche Forschungsgemeinschaft 10.13039/501100001659 CRC 974...
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Includes: Supplementary data