... of the neurogenic niche within the dentate gyrus is affected and subgranular zone development is severely impaired. Brain development Dentate gyrus Congenital malformation Congenital Zika syndrome Hippocampus Microcephaly Neurogenesis Subgranular zone Zika virus Conselho Nacional de...

... mice differed from those identified in the 6N mice. Gene expression pathways related to cell proliferation, apoptosis, and those controlling craniofacial and brain development were affected in the 6J embryos. In contrast, cellular metabolism, hypoxemia, and inflammation pathways were altered in the 6N...

... from embryos frozen within ten generations after the colony was first created in 2010. Through quantification of prenatal and postnatal brain development and several behavioral tasks, our results provide a comprehensive comparison of Ts65Dn across time and show a significant amount of variability both...

...Laura E. Kuil; Nynke Oosterhof; Samuël N. Geurts; Herma C. van der Linde; Erik Meijering; Tjakko J. van Ham ABSTRACT Microglia are brain-resident macrophages, which have specialized functions important in brain development and in disease. They colonize the brain in early embryonic stages, but few...

.... There is an expanding literature addressing the function of αDG in the nervous system, with recent reports demonstrating important roles in brain development and in the maintenance of neuronal synapses. Much of these data are derived from an increasingly rich array of experimental animal models. This Review aims...

... and adults. Altogether, our data showed widespread and unexpected fundamental differences in behavioral, gene expression and brain development phenotypes between these three mouse models. Our findings illustrate unique limitations of each model when studying aspects of brain development and function in DS...