..., but unexpectedly depended on the Jelly belly (Jeb) ligand for activation. Both Alk F1251L and Alk Y1355S mutant larval brains displayed hyperplasia, represented by increased numbers of Alk-positive neurons. Despite this hyperplasic phenotype, no brain tumors were observed in mutant animals. We showed...

... intestine, hepatic HTR2A and hepatic lipogenic gene expression, and treatment with an HTR2A antagonist reproduced these effects. The effects were milder in MC4RKO mice, and brain 5-HT and HTR2C expression did not correlate with peripheral neural blockade. Our study demonstrates that the autonomic liver-gut...

...Abbe H. Crawford; John C. W. Hildyard; Sophie A. M. Rushing; Dominic J. Wells; Maria Diez-Leon; Richard J. Piercy ABSTRACT Duchenne muscular dystrophy (DMD), a fatal musculoskeletal disease, is associated with neurodevelopmental disorders and cognitive impairment caused by brain dystrophin...

...Karissa Barthelson; Morgan Newman; Michael Lardelli ABSTRACT Energy production is the most fundamentally important cellular activity supporting all other functions, particularly in highly active organs, such as brains. Here, we summarise transcriptome analyses of young adult (pre-disease) brains...

... preclinical testing in large animal models. The minipig is a suitable experimental animal because of its large gyrencephalic brain, body weight of 70-100 kg, long lifespan, and anatomical, physiological and metabolic resemblance to humans. The Libechov transgenic minipig model for HD (TgHD) has proven useful...

... the small GTPase Rac1 is conditionally ablated in the (non-neural) surface ectoderm. Most mutant fetuses have open spina bifida, and some also exhibit exencephaly/anencephaly. However, a proportion of mutant fetuses exhibit brain herniation, affecting the occipito-parietal region and closely resembling...

... phenotypes at the (sub)cellular, brain and behavioral levels, and discuss strategies of how this extraordinarily efficient and versatile model can contribute to ‘next generation’ medical genomics and to a better understanding of these disorders. References Abbeduto , L. , McDuffie...

... medium provided that the original work is properly attributed. Summary: Dp71 is the most prominent dystrophin gene product in the adult brain. Here, multiple approaches including behavioral tests and electrophysiology are adopted to explore the role of Dp71 in the cerebellum. Dystrophin...

...Tjakko J. van Ham; Colleen A. Brady; Ruby D. Kalicharan; Nynke Oosterhof; Jeroen Kuipers; Anneke Veenstra-Algra; Klaas A. Sjollema; Randall T. Peterson; Harm H. Kampinga; Ben N. G. Giepmans Many brain diseases involve activation of resident and peripheral immune cells to clear damaged and dying...