.../by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Summary: Cercosporamide, a metabolite from the fungus Ascochyta aquiliqiae , was identified as a potent bone morphogenetic protein receptor (BMPR) type I...

... I (ACVR1). These mutations cause dysregulated bone morphogenetic protein (BMP) signalling, leading to HO at extraskeletal sites including, but not limited to, muscles, ligaments, tendons and fascia. Ever since the identification of the causative gene, developing a cure for FOP has been a focus...

... that interactions between genes and the environment play a role in the widely variable penetrance and expressivity of HPE, although direct investigation of such effects has been limited. The goal of this study was to examine whether mice carrying a mutation in a gene encoding the bone morphogenetic protein (BMP...