...Jonathan M. LaCombe; Kourtney Sloan; Jared R. Thomas; Matthew P. Blackwell; Isabella Crawford; Flannery Bishop; Joseph M. Wallace; Randall J. Roper Skeletal insufficiency affects all individuals with Down syndrome (DS) or Trisomy 21 (Ts21) and may alter bone strength throughout development due...

... of expression of the dystrophin protein isoform Dp427 and resultant dystrophic pathology in limb muscles and the diaphragm, with evidence of centrally nucleated fibers, increased inflammatory markers and fibrosis, progressive decline in muscle function, and compromised trabecular bone development. The BALB/c...

..., the development of preclinical models to study PTSD-induced bone loss remains limited. In this study, we present a previously unreported model of PTSD in adult female C57BL/6 mice, by employing inescapable foot shock and social isolation, that demonstrates high face and construct validity. A subset of mice...

...Nadia Garibaldi; Roberta Besio; Raymond Dalgleish; Simona Villani; Aileen M. Barnes; Joan C. Marini; Antonella Forlino ABSTRACT Osteogenesis imperfecta (OI) is a heterogeneous family of collagen type I-related diseases characterized by bone fragility. OI is most commonly caused by single-nucleotide...

...Sachin Wani; Anna Daroszewska; Donald M. Salter; Rob J. van ‘t Hof; Stuart H. Ralston; Omar M. E. Albagha ABSTRACT Paget's disease of bone (PDB) is characterized by focal increases in bone remodelling. Genome-wide association studies identified a susceptibility locus for PDB tagged by rs5742915...

...Monika J. Tomecka; Lalith P. Ethiraj; Luis M. Sánchez; Henry H. Roehl; Tom J. Carney ABSTRACT Reduced bone quality or mineral density predict susceptibility to fracture and also attenuate subsequent repair. Bone regrowth is also compromised by bacterial infection, which exacerbates fracture site...

...Ross Dobie; Vicky E. MacRae; Chloe Pass; Elspeth M. Milne; S. Faisal Ahmed; Colin Farquharson ABSTRACT Individuals with inflammatory bowel disease (IBD) often present with poor bone health. The development of targeted therapies for this bone loss requires a fuller understanding of the underlying...

... on bone using a well-established murine model for PTSD. C57BL/6N mice (7 weeks old) were subjected to chronic subordinate colony housing (CSC) for 19 days, whereas control mice were singly housed. Anxiety-related behavior was assessed in the open-field/novel-object test, after which the mice were...

...Mary P. Colasanto; Shai Eyal; Payam Mohassel; Michael Bamshad; Carsten G. Bonnemann; Elazar Zelzer; Anne M. Moon; Gabrielle Kardon ABSTRACT In the vertebrate limb over 40 muscles are arranged in a precise pattern of attachment via muscle connective tissue and tendon to bone and provide an extensive...

... under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Osteoarthritis Cartilage Bone Animal models...