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1-7 of 7
Keywords: Biomarkers
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Journal Articles
In collection:
Rare Disease Translational Research
Roberta Resaz, Davide Cangelosi, Martina Morini, Daniela Segalerba, Luca Mastracci, Federica Grillo, Maria Carla Bosco, Cristina Bottino, Irma Colombo, Alessandra Eva
Journal:
Disease Models & Mechanisms
Dis Model Mech (2020) 13 (9): dmm043364.
Published: 18 September 2020
... in the enzyme glucose-6-phosphatase-α (G6Pase-α), develop renal and liver complications, including the development of hepatocellular adenoma/carcinoma. The purpose of this study was to identify potential biomarkers of the pathophysiology of the GSD1a-affected liver. To this end, we used the plasma exosomes...
Includes: Supplementary data
Journal Articles
Miranda D. Grounds, Jessica R. Terrill, Basma A. Al-Mshhdani, Marisa N. Duong, Hannah G. Radley-Crabb, Peter G. Arthur
Journal:
Disease Models & Mechanisms
Dis Model Mech (2020) 13 (2): dmm043638.
Published: 2 March 2020
... are being developed, but the long lead times required when using clinical outcome measures are hindering progress. This progress would be facilitated by robust molecular biomarkers in biofluids, such as blood and urine, which could be used to monitor disease progression and severity, as well as to determine...
Journal Articles
In collection:
Rare Disease Translational Research
Marie Rodinova, Jana Krizova, Hana Stufkova, Bozena Bohuslavova, Georgina Askeland, Zaneta Dosoudilova, Stefan Juhas, Jana Juhasova, Zdenka Ellederova, Jiri Zeman, Lars Eide, Jan Motlik, Hana Hansikova
Journal:
Disease Models & Mechanisms
Dis Model Mech (2019) 12 (7): dmm038737.
Published: 26 July 2019
... protein (OPA1) and dynamin-related protein 1 (DRP1) in the skeletal muscle of TgHD minipigs. Statistical analysis identified several parameters that were dependent only on HD status and could therefore be used as potential biomarkers of disease progression. In particular, the reduction of biomarker RCCII...
Journal Articles
In collection:
Cancer
Joanna Suraj, Anna Kurpińska, Agnieszka Zakrzewska, Magdalena Sternak, Marta Stojak, Agnieszka Jasztal, Maria Walczak, Stefan Chlopicki
Journal:
Disease Models & Mechanisms
Dis Model Mech (2019) 12 (3): dmm036269.
Published: 1 March 2019
.../MS-MRM) quantification of 12 endothelium-related biomarkers, including those reflecting glycocalyx disruption – syndecan-1 (SDC-1), endocan (ESM-1); endothelial inflammation – vascular cell adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), E-selectin (E-sel); endothelial...
Journal Articles
Tammaryn Lashley, Jonathan M. Schott, Philip Weston, Christina E. Murray, Henny Wellington, Ashvini Keshavan, Sandrine C. Foti, Martha Foiani, Jamie Toombs, Jonathan D. Rohrer, Amanda Heslegrave, Henrik Zetterberg
Journal:
Disease Models & Mechanisms
Dis Model Mech (2018) 11 (5): dmm031781.
Published: 8 May 2018
... disease is currently unknown. In this ‘At a glance’ article and poster, we summarise the molecular biomarkers that are being developed to detect Alzheimer's disease and its related pathologies. We also highlight the biomarkers that are currently in clinical use and include a critical appraisal...
Includes: Supplementary data
Journal Articles
In collection:
Neurodegenerative Disorders
Suna Lahut, Suzana Gispert, Özgür Ömür, Candan Depboylu, Kay Seidel, Jorge Antolio Domínguez-Bautista, Nadine Brehm, Hülya Tireli, Karl Hackmann, Caroline Pirkevi, Barbara Leube, Vincent Ries, Kerstin Reim, Nils Brose, Wilfred F. den Dunnen, Madrid Johnson, Zsuzsanna Wolf, Marc Schindewolf, Wiebke Schrempf, Kathrin Reetz, Peter Young, David Vadasz, Achilleas S. Frangakis, Evelin Schröck, Helmuth Steinmetz, Marina Jendrach, Udo Rüb, Ayşe Nazlı Başak, Wolfgang Oertel, Georg Auburger
Journal:
Disease Models & Mechanisms
Dis Model Mech (2017) 10 (5): 619–631.
Published: 1 May 2017
... release, we studied blood samples from a new large pedigree with SNCA gene duplication (PARK4 mutation) to identify effects of SNCA gain of function as potential disease biomarkers. Downregulation of complexin 1 ( CPLX1 ) mRNA was correlated with genotype, but the expression of other Parkinson's disease...
Includes: Supplementary data
Journal Articles
Greetje Vande Velde, Jennifer Poelmans, Ellen De Langhe, Amy Hillen, Jeroen Vanoirbeek, Uwe Himmelreich, Rik J. Lories
Journal:
Disease Models & Mechanisms
Dis Model Mech (2016) 9 (1): 91–98.
Published: 1 January 2016
... processes in a field in which ex vivo assessment of experimental disease models is still the gold standard. To optimize the quantitative monitoring of progression and therapy of lung diseases, we evaluated longitudinal changes in four different micro-CT-derived biomarkers [aerated lung volume, lung tissue...
Includes: Supplementary data
