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Keywords: Bile acids
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Journal Articles
Insulin receptor substrate 2 (IRS2) deficiency delays liver fibrosis associated with cholestatic injury
Open AccessAndrea Villar-Lorenzo, Patricia Rada, Esther Rey, Patricia Marañón, Ana I. Arroba, Beatriz Santamaría, Jorge Sáiz, Francisco J. Rupérez, Coral Barbas, Carmelo García-Monzón, Ángela M. Valverde, Águeda González-Rodríguez
Journal:
Disease Models & Mechanisms
Dis Model Mech (2019) 12 (7): dmm038810.
Published: 16 July 2019
...-inflammatory profile of bile acids accumulated in the gallbladder of IRS2KO mice after BDL corresponded with the reduced expression of pro-inflammatory markers in these mice. Stable silencing of IRS2 or inhibition of ERK1/2 reduced the activation of human LX2 cells and also reduced induction of MMP9 upon IGF1...
Includes: Supplementary data
