... acquisition: S.P., T.L.W., A.G., A.P., A.E.K., A.W.H., A.L.C. Funding This work was supported by grant funding from Batten Disease Support and Research Association Australia (RGP204), Royal Hobart Hospital Research Foundation (17-205) and a National Health and Medical Research Council Dementia...

...Robert J. Huber ABSTRACT The neuronal ceroid lipofuscinoses (NCLs), collectively known as Batten disease, are a group of neurological diseases that affect all ages and ethnicities worldwide. There are 13 different subtypes of NCL, each caused by a mutation in a distinct gene. The NCLs...

... attributed. Editors’ choice: This study demonstrates neurogenic alterations in the most common neurodegenerative disease of children and reports a novel function of the CLN5 protein. Neurogenesis Neuronal ceroid lipofuscinoses Batten disease Lysosomal storage disease Stem cells CLN5...

...Attila D. Kovács; David A. Pearce Mutations in the CLN3 gene cause a fatal neurodegenerative disorder: juvenile CLN3 disease, also known as juvenile Batten disease. The two most commonly utilized mouse models of juvenile CLN3 disease are Cln3 -knockout ( Cln3 −/− ) and Cln3 Δex7/8 -knock-in mice...

... work is properly attributed. Neuronal ceroid lipofuscinosis Batten disease TPP1 Tripeptidyl peptidase 1 Dictyostelium Neuronal ceroid lipofuscinosis (NCL), or Batten disease, is the most common childhood-onset neurodegenerative disease, and it is characterized by a progressive...