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Keywords: BDNF
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Journal Articles

A small-molecule TrkB ligand improves dendritic spine phenotypes and atypical behaviors in female Rett syndrome mice

In collection:
Developmental Disorders , Rare Disease Translational Research
Destynie Medeiros, Karen Ayala-Baylon, Hailey Egido-Betancourt, Eric Miller, Christopher Chapleau, Holly Robinson, Mary L. Phillips, Tao Yang, Frank M. Longo, Wei Li, Lucas Pozzo-Miller
Journal: Disease Models & Mechanisms
Dis Model Mech (2024) 17 (6): dmm050612.
https://doi.org/10.1242/dmm.050612
Published: 24 May 2024
...-CpG-binding protein 2, a transcriptional regulator of many genes, including brain-derived neurotrophic factor ( BDNF ). BDNF levels are lower in multiple brain regions of Mecp2 -deficient mice, and experimentally increasing BDNF levels improve atypical phenotypes in Mecp2 mutant mice. Due to the low...
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Includes: Supplementary data
Journal Articles

Increased levels of synaptic proteins involved in synaptic plasticity after chronic intraocular pressure elevation and modulation by brain-derived neurotrophic factor in a glaucoma animal model

In collection:
Rat as a Disease Model
Hae-Young Lopilly Park, Si Won Kim, Jie Hyun Kim, Chan Kee Park
Journal: Disease Models & Mechanisms
Dis Model Mech (2019) 12 (6): dmm037184.
https://doi.org/10.1242/dmm.037184
Published: 18 June 2019
... may critically alter the function of RGCs in glaucoma. The present study attempted to discover changes in the synapse using brain-derived neurotrophic factor (BDNF) after glaucoma induction by chronic intraocular pressure elevation in a rat model. Immunohistochemical staining revealed that the BDNF...
View article titled, Increased levels of synaptic proteins involved in synaptic plasticity after chronic intraocular pressure elevation and modulation by brain-derived neurotrophic factor in a glaucoma animal model
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Journal Articles

A small-molecule TrkB ligand restores hippocampal synaptic plasticity and object location memory in Rett syndrome mice

Wei Li, Alba Bellot-Saez, Mary L. Phillips, Tao Yang, Frank M. Longo, Lucas Pozzo-Miller
Journal: Disease Models & Mechanisms
Dis Model Mech (2017) 10 (7): 837–845.
https://doi.org/10.1242/dmm.029959
Published: 1 July 2017
... factor ( BDNF ). BDNF levels are reduced in RTT autopsy brains and in multiple brain areas of Mecp2 -deficient mice. Furthermore, experimental interventions that increase BDNF levels improve RTT-like phenotypes in Mecp2 mutant mice. Here, we characterized the actions of a small-molecule ligand...
View article titled, A small-molecule TrkB ligand restores hippocampal synaptic plasticity and object location memory in Rett syndrome mice
Open the PDF for A small-molecule TrkB ligand restores hippocampal synaptic plasticity and object location memory in Rett syndrome mice in another window
Includes: Supplementary data