... of mice. MEK1 S217/221E expression led to persistent hyperactivation of ERK1/2 in cortical axons, but not in soma/nuclei. We noted reduced axonal arborization in multiple target domains in mutant mice and reduced the levels of the activity-dependent protein ARC. These changes did not lead to deficits...

... neuronal morphology and contribute to neuronal aberrations in DS. Here, we report the functional interaction between the Drosophila homologs of these two genes, Amyloid precursor protein-like ( Appl ) and Dscam ( Dscam1 ). We show that Appl requires Dscam to promote axon terminal growth in sensory neurons...

...Kelley C. O’Donnell; Aaron Lulla; Mark C. Stahl; Nickolas D. Wheat; Jeff M. Bronstein; Alvaro Sagasti α-synuclein (aSyn) expression is implicated in neurodegenerative processes, including Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). In animal models of these diseases, axon...