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Keywords: Autonomic neuron
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Journal Articles

Involvement of the liver-gut peripheral neural axis in nonalcoholic fatty liver disease pathologies via hepatic HTR2A

Open Access
In collection:
Metabolic Disorders
Takashi Owaki, Kenya Kamimura, Masayoshi Ko, Itsuo Nagayama, Takuro Nagoya, Osamu Shibata, Chiyumi Oda, Shinichi Morita, Atsushi Kimura, Takeki Sato, Toru Setsu, Akira Sakamaki, Hiroteru Kamimura, Takeshi Yokoo, Shuji Terai
Journal: Disease Models & Mechanisms
Dis Model Mech (2022) 15 (7): dmm049612.
https://doi.org/10.1242/dmm.049612
Published: 26 July 2022
... 18K19537 21K19478 Fatty liver Autonomic neuron 5-HT Antagonist Brain Summary: The hepatic-gut neural axis plays a role in NAFLD progression via serotonin and the serotonin receptor HTR2A in hepatocytes, suggesting that HTR2A antagonists are potential therapeutic agents for NAFLD. ©...
View articletitled, Involvement of the liver-gut peripheral neural axis in nonalcoholic fatty liver disease pathologies via hepatic HTR2A
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Includes: Supplementary data
Journal Articles

Modulation of serotonin in the gut-liver neural axis ameliorates the fatty and fibrotic changes in non-alcoholic fatty liver

Open Access
In collection:
Metabolic Disorders
Masayoshi Ko, Kenya Kamimura, Takashi Owaki, Takuro Nagoya, Norihiro Sakai, Itsuo Nagayama, Yusuke Niwa, Osamu Shibata, Chiyumi Oda, Shinichi Morita, Atsushi Kimura, Ryosuke Inoue, Toru Setsu, Akira Sakamaki, Takeshi Yokoo, Shuji Terai
Journal: Disease Models & Mechanisms
Dis Model Mech (2021) 14 (3): dmm048922.
https://doi.org/10.1242/dmm.048922
Published: 28 March 2021
.... Summary: The gut-liver neural axis is involved in NAFLD progression and serotonin is the key factor in allowing this pathway to change the expression of tight junction molecules, microbiota diversity and short-chain fatty acids. Fatty liver Autonomic neuron Obesity Diet Hormone...
View articletitled, Modulation of serotonin in the gut-liver neural axis ameliorates the fatty and fibrotic changes in non-alcoholic fatty liver
Open the PDF for Modulation of serotonin in the gut-liver neural axis ameliorates the fatty and fibrotic changes in non-alcoholic fatty liver in another window
Includes: Supplementary data