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Keywords: Ataxia
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Journal Articles
Dis Model Mech (2024) 17 (6): dmm050379.
Published: 12 June 2024
...Luis E. Salazar Leon; Amanda M. Brown; Heet Kaku; Roy V. Sillitoe ABSTRACT Purkinje cell dysfunction disrupts movement and causes disorders such as ataxia. Recent evidence suggests that Purkinje cell dysfunction may also alter sleep regulation. Here, we used an ataxic mouse model generated...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Dis Model Mech (2021) 14 (6): dmm044834.
Published: 24 June 2021
...Thomas P. Zwaka; Marta Skowronska; Ronald Richman; Marion Dejosez ABSTRACT Spinocerebellar ataxias (SCAs) are a group of genetically heterogeneous inherited neurodegenerative disorders characterized by progressive ataxia and cerebellar degeneration. Here, we used a mouse model to test a possible...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2016) 9 (5): 553–562.
Published: 1 May 2016
... of progressive Purkinje cell (PC) degeneration exhibiting a shaking ataxia and wide stance. Generation of Wistar Furth (WF)/Brown Norwegian (BN) F1 hybrids and genetic mapping of F2 sib-sib offspring using polymorphic markers narrowed the candidate gene region to 26 Mbp denoted by the last recombinant genetic...
Includes: Supplementary data