...Annesha C. King; Emily Payne; Emily Stephens; Jahmel A. Fowler; Tara E. Wood; Efrain Rodriguez; Michelle Gray ABSTRACT Huntington's disease (HD) is a fatal, progressive neurodegenerative disorder. Prior studies revealed an increase in extracellular glutamate levels after evoking astrocytic SNARE...

... a novel form of intercellular communication, have been shown to influence the function/vulnerability of neurons in AD. Unlike neurons, the significance of exosomes derived from astrocytes remains unclear. In this study, we evaluated the significance of exosomes derived from U18666A-induced cholesterol...

... ). Descriptions of other neuropathological features of these mutant mice show some inconsistencies; whereas one group reported localized demyelination and noted loss of oligodendrocytes ( Qin et al., 2018 ), another reported normal axon numbers and myelination but reactive astrocytes in the CNS ( Wong et al...

... with human astrocytes and oligodendrocytes. Human glia were in periventricular areas, white matter tracts, the olfactory bulb and the brain stem. HIV-1 infection led to meningeal and perivascular human leukocyte infiltration into the brain. Species-specific viral-neuroimmune interactions were identified...

... and BLBP, typical of type one radial glial cells (RGs) from the subgranular zone. These cells had altered expression of CCND1 and NOTCH1 and decreased expression of several ribosomal RNA genes. We found that these cells were able to differentiate into astrocytes upon directed differentiation...