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Keywords: Arap1
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Journal Articles
Arap1 loss causes retinal pigment epithelium phagocytic dysfunction and subsequent photoreceptor death
Open AccessIn collection:
Human Genetic Disease
Andy Shao, Antonio Jacobo Lopez, JiaJia Chen, Addy Tham, Seanne Javier, Alejandra Quiroz, Sonia Frick, Edward M. Levine, K. C. Kent Lloyd, Brian C. Leonard, Christopher J. Murphy, Thomas M. Glaser, Ala Moshiri
Journal:
Disease Models & Mechanisms
Dis Model Mech (2022) 15 (7): dmm049343.
Published: 25 July 2022
... of heritable blindness. Previously, we described that Arap1 −/− mice develop a similar pattern of photoreceptor degeneration. Arap1 is an Arf-directed GTPase-activating protein shown to modulate actin cytoskeletal dynamics. Curiously, Arap1 expression was detected in Müller glia and retinal pigment epithelium...
Includes: Supplementary data
