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1-4 of 4
Keywords: ApoE
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Journal Articles
Sex-dependent effect of APOE on Alzheimer's disease and other age-related neurodegenerative disorders
Open AccessIn collection:
Neurodegenerative Disorders
Journal:
Disease Models & Mechanisms
Dis Model Mech (2020) 13 (8): dmm045211.
Published: 27 August 2020
...Julia Gamache; Young Yun; Ornit Chiba-Falek ABSTRACT The importance of apolipoprotein E (APOE) in late-onset Alzheimer's disease (LOAD) has been firmly established, but the mechanisms through which it exerts its pathogenic effects remain elusive. In addition, the sex-dependent effects of APOE...
Journal Articles
Edward F. Griffin, Samuel E. Scopel, Cayman A. Stephen, Adam C. Holzhauer, Madeline A. Vaji, Ryan A. Tuckey, Laura A. Berkowitz, Kim A. Caldwell, Guy A. Caldwell
Journal:
Disease Models & Mechanisms
Dis Model Mech (2019) 12 (2): dmm037218.
Published: 15 February 2019
...Edward F. Griffin; Samuel E. Scopel; Cayman A. Stephen; Adam C. Holzhauer; Madeline A. Vaji; Ryan A. Tuckey; Laura A. Berkowitz; Kim A. Caldwell; Guy A. Caldwell ABSTRACT Allele-specific distinctions in the human apolipoprotein E (APOE) locus represent the best-characterized genetic predictor...
Journal Articles
Bin Fang, Xueyang Ren, Ying Wang, Ze Li, Lihua Zhao, Manling Zhang, Chu Li, Zhengwei Zhang, Lei Chen, Xiaoxue Li, Jiying Liu, Qiang Xiong, Lining Zhang, Yong Jin, Xiaorui Liu, Lin Li, Hong Wei, Haiyuan Yang, Rongfeng Li, Yifan Dai
Journal:
Disease Models & Mechanisms
Dis Model Mech (2018) 11 (10): dmm036632.
Published: 10 October 2018
... atherosclerosis because their cardiovascular system and physiology are similar to that of humans. Apolipoprotein E (ApoE) deficiency has long been implicated in cardiovascular disease in humans. To establish an improved large animal model of familial hypercholesterolemia and atherosclerosis, the clustered...
Includes: Supplementary data
Journal Articles
Xugang Wang, Rong Huang, Lichen Zhang, Saichao Li, Jing Luo, Yanrong Gu, Zhijun Chen, Qianqian Zheng, Tianzhu Chao, Wenping Zheng, Xinhui Qi, Li Wang, Yinhang Wen, Yinming Liang, Liaoxun Lu
Journal:
Disease Models & Mechanisms
Dis Model Mech (2018) 11 (10): dmm033852.
Published: 8 October 2018
... atherosclerosis development in the NOD strain is of particular interest as human atherosclerosis on the diabetic and autoimmune background has not been successfully modeled. In this study, we used CRISPR/Cas9 genome editing to genetically disrupt apolipoprotein E (ApoE) and low-density lipoprotein receptor (LDLR...
Includes: Supplementary data
