1-2 of 2
Keywords: Antisense oligonucleotide
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
Dis Model Mech (2022) 15 (7): dmm049284.
Published: 25 July 2022
... was then used to test the therapeutic efficacy of Dnm2 targeting. Dnm2 reduction by antisense oligonucleotides blocked or postponed disease development, and resulted in a significant dose-dependent improvement outside the expected disease progression in untreated Mtm1 −/y mice. This provides an example...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (2): dmm040832.
Published: 4 November 2019
... ) gene. The most common SGCG mutation is a single nucleotide deletion from a stretch of five thymine residues in SGCG exon 6 (521ΔT). This founder mutation disrupts the transcript reading frame, abolishing protein expression. An antisense oligonucleotide exon-skipping method to reframe the human 521ΔT...
Includes: Supplementary data