... abnormalities in a zebrafish genetic model of hereditary haemorrhagic telangiectasia were prevented by synergistic inhibition of the MEK and mTOR pathways downstream of Vegf, suggesting a potential novel therapeutic approach. Zebrafish Endoglin Angiogenesis HHT VEGF British Heart Foundation...

...Denver D. Britto; Barbara Wyroba; Wenxuan Chen; Rhoswen A. Lockwood; Khanh B. Tran; Peter R. Shepherd; Christopher J. Hall; Kathryn E. Crosier; Philip S. Crosier; Jonathan W. Astin ABSTRACT Tumour angiogenesis has long been a focus of anti-cancer therapy; however, anti-angiogenic cancer treatment...

...Eunate Gallardo-Vara; Simon Tual-Chalot; Luisa M. Botella; Helen M. Arthur; Carmelo Bernabeu ABSTRACT Endoglin is a transmembrane glycoprotein expressed in vascular endothelium that plays a key role in angiogenesis. Mutations in the endoglin gene ( ENG ) cause hereditary hemorrhagic telangiectasia...

... cardiac functions, beneficial remodeling and increased capillary density 6 weeks after MI. Concomitant fluorescence-activated cell sorting, co-cultures with neonatal cardiomyocytes, angiogenesis assays, ELISA, western blotting and RAMAN spectroscopy demonstrated that EPO could promote cardiomyogenic...

... zebrafish larvae to 2% ethanol for 24 h induced hepatic steatosis, angiogenesis and fibrogenesis. The liver started self-repair once ethanol was removed. Although inhibiting Kdrl did not block the initial activation of hepatic stellate cells during ethanol treatment, it suppressed their proliferation...

... growth in the long term, which suggests that the tumour vasculature escapes from angiogenesis inhibition through αvβ3-integrin-independent mechanisms. Here, we show that suppression of β3-integrin in mice leads to the activation of a neuropilin-1 (NRP1)-dependent cell migration pathway in endothelial...

...Milad S. Bitar; Fahd Al-Mulla Impaired angiogenesis and endothelial dysfunction in type 2 diabetes constitute dominant risk factors for non-healing wounds and most forms of cardiovascular disease. We propose that diabetes shifts the ‘angiogenic balance’ in favor of an excessive anti-angiogenic...

...Charu Munjal; Amy M. Opoka; Hanna Osinska; Jeanne F. James; Giorgio M. Bressan; Robert B. Hinton Aortic valve disease (AVD) is characterized by elastic fiber fragmentation (EFF), fibrosis and aberrant angiogenesis. Emilin1 is an elastin-binding glycoprotein that regulates elastogenesis and inhibits...

... or tumors exposed to radiation alone. Several biomarkers were investigated to evaluate cell proliferation (Ki67), blood leakage (factor VIII), angiogenesis (cluster of differentiation molecule CD31), ceramide-formation, angiogenesis signaling [vascular endothelial growth factor (VEGF)], oxygen limitation...

... in microvessels . Microvasc. Res.   7 , 131 – 143 . Feng   D. , Welker   S. , Körbel   C. , Rudzitis-Auth   J. , Menger   M. D. , Montenarh   M. , Laschke   M. W. ( 2012 ). Protein kinase CK2 is a regulator of angiogenesis in endometriotic lesions . Angiogenesis   15 , 243 – 252...