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Keywords: Amyotrophic lateral sclerosis
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Journal Articles
In collection:
Neurodegeneration
Dis Model Mech (2023) 16 (10): dmm049851.
Published: 13 October 2023
...Mara Prior-González; Rafael Lazo-Gómez; Ricardo Tapia ABSTRACT Motor neuron (MN) loss is the primary pathological hallmark of amyotrophic lateral sclerosis (ALS). Histone deacetylase 4 (HDAC4) is one of several factors involved in nerve–muscle communication during MN loss, hindering muscle...
Includes: Supplementary data
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Journal Articles
Dis Model Mech (2022) 15 (8): dmm049059.
Published: 29 August 2022
... of cell senescence in the lumbar spinal cord, with selective sensitivity to senolytic treatments. Amyotrophic lateral sclerosis Navitoclax Senolytic Neuroinflammation Therapy Cell cycle Cryptic exon Instituto de Salud Carlos III http://dx.doi.org/10.13039/501100004587 PI 17-00134...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2022) 15 (4): dmm049032.
Published: 29 April 2022
... different ages. Furthermore, epigenetic control was observed in mouse and human cultured cell lines. In amyotrophic lateral sclerosis, the formation of TDP-43-containing brain inclusions removes functional protein from the system. This phenomenon is continuous but compensated by newly synthesized protein...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2021) 14 (11): dmm049092.
Published: 1 December 2021
...) and amyotrophic lateral sclerosis (ALS). This repeat expansion can be translated into dipeptide repeat proteins (DPRs), and distribution of the poly-GR DPR correlates with neurodegeneration in postmortem C9FTD/ALS brains. Here, we assessed poly-GR toxicity in zebrafish embryos, using an annexin A5-based...
Includes: Supplementary data
Journal Articles
In collection:
Neurodegeneration
Dis Model Mech (2021) 14 (2): dmm047548.
Published: 11 February 2021
... and enhanced by a mutation associated with familial amyotrophic lateral sclerosis . J. Neurosci. 30 , 639 - 649 . 10.1523/JNEUROSCI.4988-09.2010 Bates , D. , Mächler , M. , Bolker , B. and Walker , S. ( 2015 ). Fitting linear mixed-effects models using lme4 . J. Stat. Softw...
Includes: Supplementary data
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Journal Articles
Dis Model Mech (2020) 13 (7): dmm044867.
Published: 7 July 2020
... muscle Motor neurons Amyotrophic lateral sclerosis Induced pluripotent stem cells Tissue engineering Microfluidic devices Neuromuscular diseases collectively affect 160 per 100,000 people worldwide and are generally characterized by progressive motor impairment and muscular atrophy ( Deenen...
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Journal Articles
Dis Model Mech (2019) 12 (8): dmm039552.
Published: 16 August 2019
...Eileen Lynch; Theran Semrad; Vincent S. Belsito; Claire FitzGibbons; Megan Reilly; Koji Hayakawa; Masatoshi Suzuki ABSTRACT Amyotrophic lateral sclerosis (ALS) is a late-onset neuromuscular disease with no cure and limited treatment options. Patients experience a gradual paralysis leading to death...
Includes: Supplementary data
Journal Articles
In collection:
Neurodegeneration
Dis Model Mech (2019) 12 (8): dmm040238.
Published: 13 August 2019
...Martin Crivello; Marion C. Hogg; Elisabeth Jirström; Luise Halang; Ina Woods; Megan Rayner; Karen S. Coughlan; Sebastian A. Lewandowski; Jochen H. M. Prehn ABSTRACT Amyotrophic lateral sclerosis (ALS) presents a poorly understood pathogenesis. Evidence from patients and mutant SOD1 mouse models...
Includes: Supplementary data
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