...Taylor R. Stanley; Elizabeth M. Otero; Amy L. Knight; Aleen D. Saxton; Xinxing Ding; Melissa Borgen; Brian C. Kraemer; Karen S. Kim Guisbert; Eric Guisbert ABSTRACT Alzheimer's disease is associated with the misfolding and aggregation of two distinct proteins, beta-amyloid and tau. Previously...

... . 10.1016/J.NEUROSCIENCE.2022.05.022 Ginsberg , S. D. , Crino , P. B. , Lee , V. M. Y. , Eberwine , J. H. and Trojanowski , J. Q. ( 1997 ). Sequestration of RNA in Alzheimer's disease neurofibrillary tangles and senile plaques . Ann. Neurol. 41 , 200 - 209 . 10.1002/ANA...

...Jimena Monzón-Sandoval; Elena Burlacu; Devika Agarwal; Adam E. Handel; Liting Wei; John Davis; Sally A. Cowley; M. Zameel Cader; Caleb Webber ABSTRACT Alzheimer's disease (AD) is the most common form of dementia, and risk-influencing genetics implicates microglia and neuroimmunity...

...Emily J. Koller; Melissa Comstock; Jonathan C. Bean; Gabriel Escobedo, Jr; Kyung-Won Park; Joanna L. Jankowsky ABSTRACT Although a large number of mouse models have been made to study Alzheimer's disease, only a handful allow experimental control over the location or timing of the protein being...

...Caitlin S. Latimer; Jade G. Stair; Joshua C. Hincks; Heather N. Currey; Thomas D. Bird; C. Dirk Keene; Brian C. Kraemer; Nicole F. Liachko ABSTRACT Although amyloid β (Aβ) and tau aggregates define the neuropathology of Alzheimer's disease (AD), TDP-43 has recently emerged as a co-morbid pathology...

... from a collection of 11 early-onset familial Alzheimer's disease (EOFAD)-like and non-EOFAD-like mutations in three zebrafish genes. The one cellular activity consistently predicted as affected by only the EOFAD-like mutations is oxidative phosphorylation, which produces most of the energy of the brain...

...Qi Wu; Leonardo Cortez; Razieh Kamali-Jamil; Valerie Sim; Holger Wille; Satyabrata Kar ABSTRACT Amyloid β (Aβ) peptides generated from the amyloid precursor protein (APP) play a critical role in the development of Alzheimer's disease (AD) pathology. Aβ-containing neuronal exosomes, which represent...

... and are characterized by cognitive decline and locomotor deficits. Alzheimer's disease is the most common form of dementia, and one of the largely studied diseases. However, the cellular processes taking place remain unclear. Drosophila melanogaster is an emerging neurodegeneration model due to its versatility...

...Julia Gamache; Young Yun; Ornit Chiba-Falek ABSTRACT The importance of apolipoprotein E ( APOE ) in late-onset Alzheimer's disease (LOAD) has been firmly established, but the mechanisms through which it exerts its pathogenic effects remain elusive. In addition, the sex-dependent effects of APOE...

...Eleftheria Pervolaraki; Stephen P. Hall; Denise Foresteire; Takashi Saito; Takaomi C. Saido; Miles A. Whittington; Colin Lever; James Dachtler ABSTRACT We studied a new amyloid-beta precursor protein ( App ) knock-in mouse model of Alzheimer's disease ( App NL-G-F ), containing the Swedish KM670...

... of Alzheimer's disease (AD) risk. Expression of isoform APOE ε2 is associated with reduced risk, while APOE ε3 is neutral and APOE ε4 carriers exhibit increased susceptibility. Using Caenorhabditis elegans , we generated a novel suite of humanized transgenic nematodes to facilitate neuronal modeling of amyloid...

...Mazen Asaad; Jin Hyung Lee ABSTRACT Alzheimer's disease is a leading healthcare challenge facing our society today. Functional magnetic resonance imaging (fMRI) of the brain has played an important role in our efforts to understand how Alzheimer's disease alters brain function. Using fMRI in animal...

...Tammaryn Lashley; Jonathan M. Schott; Philip Weston; Christina E. Murray; Henny Wellington; Ashvini Keshavan; Sandrine C. Foti; Martha Foiani; Jamie Toombs; Jonathan D. Rohrer; Amanda Heslegrave; Henrik Zetterberg ABSTRACT The neurodegenerative disorder Alzheimer's disease is characterised...

... using a classical pharmacological approach. Curcumin, the main curcuminoid of turmeric, is a complex molecule possessing wide-ranging biological activities, cellular mechanisms and roles in potential therapeutic treatment, including Alzheimer's disease and cancer. Here, we investigate the physiological...

...Piyali Majumder; Kasturi Roy; Brijesh Kumar Singh; Nihar Ranjan Jana; Debashis Mukhopadhyay ABSTRACT Alzheimer's disease (AD) manifests as neuronal loss. On the premise of Grb2 overexpression in AD mouse brain and brain tissues of AD patients, our study primarily focuses on the stability...

...Vito Antonio Baldassarro; Alessandra Marchesini; Luciana Giardino; Laura Calzà ABSTRACT Microvascular dysfunction is considered an integral part of Alzheimer disease (AD) pathogenesis, but the possible relationship between amyloid pathology, microvascular dysfunction and cell death is still unclear...

...Jan Olsson; Hugo Lövheim; Emma Honkala; Pekka J. Karhunen; Fredrik Elgh; Eloise H. Kok ABSTRACT Herpes simplex virus (HSV) type 1 affects a majority of the population and recent evidence suggests involvement in Alzheimer's disease aetiology. We investigated the prevalence of HSV type 1 and 2...

... pathogenic factor in Down syndrome and Alzheimer's disease. Thus, inhibition of DYRK1A has been suggested to be a new strategy to modify the disease. Very few compounds, however, have been reported to act as inhibitors, and their potential clinical uses require further evaluation. Here, we newly identify CX...

...Anne-Laure Bougé; Marie-Laure Parmentier ABSTRACT In neurodegenerative diseases such as Alzheimer's disease (AD), cell cycle defects and associated aneuploidy have been described. However, the importance of these defects in the physiopathology of AD and the underlying mechanistic processes...

... of individuals with Down syndrome (DS) or Alzheimer's disease (AD). Although increased levels of DSCR1 were often observed to be deleterious to neuronal health, its beneficial effects against AD neuropathology have also been reported, and the roles of DSCR1 on the pathogenesis of AD remain controversial. Here...