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Keywords: Alzheimer's disease
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Journal Articles
Dis Model Mech (2020) 13 (8): dmm045211.
Published: 27 August 2020
...Julia Gamache; Young Yun; Ornit Chiba-Falek ABSTRACT The importance of apolipoprotein E ( APOE ) in late-onset Alzheimer's disease (LOAD) has been firmly established, but the mechanisms through which it exerts its pathogenic effects remain elusive. In addition, the sex-dependent effects of APOE on...
Journal Articles
Dis Model Mech (2019) 12 (9): dmm040550.
Published: 24 September 2019
...Eleftheria Pervolaraki; Stephen P. Hall; Denise Foresteire; Takashi Saito; Takaomi C. Saido; Miles A. Whittington; Colin Lever; James Dachtler ABSTRACT We studied a new amyloid-beta precursor protein ( App ) knock-in mouse model of Alzheimer's disease ( App NL-G-F ), containing the Swedish KM670...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2019) 12 (2): dmm037218.
Published: 15 February 2019
... Alzheimer's disease (AD) risk. Expression of isoform APOE ε2 is associated with reduced risk, while APOE ε3 is neutral and APOE ε4 carriers exhibit increased susceptibility. Using Caenorhabditis elegans , we generated a novel suite of humanized transgenic nematodes to facilitate neuronal modeling of amyloid...
Journal Articles
Dis Model Mech (2018) 11 (5): dmm031724.
Published: 18 May 2018
...Mazen Asaad; Jin Hyung Lee ABSTRACT Alzheimer's disease is a leading healthcare challenge facing our society today. Functional magnetic resonance imaging (fMRI) of the brain has played an important role in our efforts to understand how Alzheimer's disease alters brain function. Using fMRI in animal...
Journal Articles
Dis Model Mech (2018) 11 (5): dmm031781.
Published: 08 May 2018
...Tammaryn Lashley; Jonathan M. Schott; Philip Weston; Christina E. Murray; Henny Wellington; Ashvini Keshavan; Sandrine C. Foti; Martha Foiani; Jamie Toombs; Jonathan D. Rohrer; Amanda Heslegrave; Henrik Zetterberg ABSTRACT The neurodegenerative disorder Alzheimer's disease is characterised by the...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2018) 11 (1): dmm032375.
Published: 29 January 2018
... using a classical pharmacological approach. Curcumin, the main curcuminoid of turmeric, is a complex molecule possessing wide-ranging biological activities, cellular mechanisms and roles in potential therapeutic treatment, including Alzheimer's disease and cancer. Here, we investigate the physiological...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2017) 10 (5): 655–669.
Published: 01 May 2017
...Piyali Majumder; Kasturi Roy; Brijesh Kumar Singh; Nihar Ranjan Jana; Debashis Mukhopadhyay ABSTRACT Alzheimer's disease (AD) manifests as neuronal loss. On the premise of Grb2 overexpression in AD mouse brain and brain tissues of AD patients, our study primarily focuses on the stability of...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2017) 10 (5): 671–678.
Published: 01 May 2017
...Vito Antonio Baldassarro; Alessandra Marchesini; Luciana Giardino; Laura Calzà ABSTRACT Microvascular dysfunction is considered an integral part of Alzheimer disease (AD) pathogenesis, but the possible relationship between amyloid pathology, microvascular dysfunction and cell death is still unclear...
Journal Articles
Dis Model Mech (2016) 9 (11): 1349–1355.
Published: 01 November 2016
...Jan Olsson; Hugo Lövheim; Emma Honkala; Pekka J. Karhunen; Fredrik Elgh; Eloise H. Kok ABSTRACT Herpes simplex virus (HSV) type 1 affects a majority of the population and recent evidence suggests involvement in Alzheimer's disease aetiology. We investigated the prevalence of HSV type 1 and 2 in the...
Journal Articles
Dis Model Mech (2016) 9 (8): 839–848.
Published: 01 August 2016
... pathogenic factor in Down syndrome and Alzheimer's disease. Thus, inhibition of DYRK1A has been suggested to be a new strategy to modify the disease. Very few compounds, however, have been reported to act as inhibitors, and their potential clinical uses require further evaluation. Here, we newly identify CX...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2016) 9 (3): 295–306.
Published: 01 March 2016
... individuals with Down syndrome (DS) or Alzheimer's disease (AD). Although increased levels of DSCR1 were often observed to be deleterious to neuronal health, its beneficial effects against AD neuropathology have also been reported, and the roles of DSCR1 on the pathogenesis of AD remain controversial. Here...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2016) 9 (3): 307–319.
Published: 01 March 2016
...Anne-Laure Bougé; Marie-Laure Parmentier ABSTRACT In neurodegenerative diseases such as Alzheimer's disease (AD), cell cycle defects and associated aneuploidy have been described. However, the importance of these defects in the physiopathology of AD and the underlying mechanistic processes are...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2015) 8 (10): 1265–1278.
Published: 01 October 2015
...Vanessa J. Hall; Maiken M. Lindblad; Jannik E. Jakobsen; Anders Gunnarsson; Mette Schmidt; Mikkel A. Rasmussen; Daniela Volke; Thole Zuchner; Poul Hyttel ABSTRACT Animal models of familial juvenile onset of Alzheimer's disease (AD) often fail to produce diverse pathological features of the disease...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2015) 8 (7): 657–667.
Published: 01 July 2015
...Stanislav Ott; Nikolas Dziadulewicz; Damian C. Crowther ABSTRACT Metals, including iron, are present at high concentrations in amyloid plaques in individuals with Alzheimer's disease, where they are also thought to be cofactors in generating oxidative stress and modulating amyloid formation. In...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2014) 7 (12): 1385–1395.
Published: 01 December 2014
...Qi Wang; Bing Xiao; Shuqin Cui; Hailong Song; Yanjing Qian; Lin Dong; Haiting An; Yanqiu Cui; Wenjing Zhang; Yi He; Jianliang Zhang; Jian Yang; Feilong Zhang; Guanzheng Hu; Xiaoli Gong; Zhen Yan; Yan Zheng; Xiaomin Wang The complex pathogenesis of Alzheimer’s disease (AD) involves multiple...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2014) 7 (6): 659–665.
Published: 01 June 2014
...Erik Hermansson; Sebastian Schultz; Damian Crowther; Sara Linse; Bengt Winblad; Gunilla Westermark; Jan Johansson; Jenny Presto Aggregation of the amyloid-β peptide (Aβ) into toxic oligomers and amyloid fibrils is linked to the development of Alzheimer’s disease (AD). Mutations of the BRICHOS...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2014) 7 (4): 445–458.
Published: 01 April 2014
...Ko-Fan Chen; Bernard Possidente; David A. Lomas; Damian C. Crowther Circadian behavioural deficits, including sleep irregularity and restlessness in the evening, are a distressing early feature of Alzheimer’s disease (AD). We have investigated these phenomena by studying the circadian behaviour of...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2014) 7 (3): 373–385.
Published: 01 March 2014
...Siddhita D. Mhatre; Vivek Satyasi; Mark Killen; Brie E. Paddock; Robert D. Moir; Aleister J. Saunders; Daniel R. Marenda Alzheimer’s disease (AD) is an age-related neurodegenerative disease characterized by memory loss and decreased synaptic function. Advances in transgenic animal models of AD have...
Includes: Supplementary data