... advances in the manipulation of the rat genome, combined with a growing recognition of the physiological differences between mice and rats, have reignited interest in the rat as a model of human cancer. Two recently developed rat models, the polyposis in the rat colon (Pirc) and Kyoto Apc Delta (KAD...

...Alexander J. Valvezan; Jian Huang; Christopher J. Lengner; Michael Pack; Peter S. Klein Truncating mutations in adenomatous polyposis coli ( APC ) are strongly linked to colorectal cancers. APC is a negative regulator of the Wnt pathway and constitutive Wnt activation mediated by enhanced Wnt–β...