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Keywords: ALS
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Dis Model Mech (2019) 12 (8): dmm038174.
Published: 13 August 2019
...Jonathan R. Volpatti; Almundher Al-Maawali; Lindsay Smith; Aqeela Al-Hashim; Julie A. Brill; James J. Dowling ABSTRACT Phosphoinositides (PIPs) are a ubiquitous group of seven low-abundance phospholipids that play a crucial role in defining localized membrane properties and that regulate myriad...
Includes: Supplementary data
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Dis Model Mech (2014) 7 (9): 1101–1109.
Published: 1 September 2014
... mechanisms in the central nervous system. In particular, P2X7 has been shown to be implicated in neuropsychiatry, chronic pain, neurodegeneration and neuroinflammation. Remarkably, P2X7 has also been shown to be a ‘gene modifier’ in amyotrophic lateral sclerosis (ALS): the receptor is upregulated in spinal...
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Dis Model Mech (2014) 7 (7): 799–809.
Published: 1 July 2014
... sclerosis (ALS) and hereditary spastic paraplegia (HSP). These studies indicate the power of zebrafish as a model to study the consequences of disease-related genes, because zebrafish homologues of human genes have conserved functions with respect to the aetiology of MNDs. Zebrafish also complement other...
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Dis Model Mech (2014) 7 (2): 233–243.
Published: 1 February 2014
... the potential for torsinA to serve as a buffer to attenuate the cellular consequences of misfolded-protein stress as it pertains to the neurodegenerative disease amyotrophic lateral sclerosis (ALS). The selective vulnerability of motor neurons to degeneration in ALS mouse models harboring mutations...
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