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Keywords: β-Catenin
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Journal Articles

A 3D adipogenesis platform to study the fate of fibro/adipogenic progenitors in muscular dystrophies

In collection:
Neuromuscular Disease
Alessio Reggio, Francesca De Paolis, Salma Bousselmi, Felice Cicciarelli, Sergio Bernardini, Alberto Rainer, Dror Seliktar, Stefano Testa, Carmine Cirillo, Paolo Grumati, Stefano Cannata, Claudia Fuoco, Cesare Gargioli
Journal: Disease Models & Mechanisms
Dis Model Mech (2023) 16 (6): dmm049915.
https://doi.org/10.1242/dmm.049915
Published: 23 June 2023
... that LY2090314 interferes with a genuine adipogenic program acting as WNT surrogate for the stabilization of a competent β-catenin transcriptional complex. To predict the beneficial impact of LY2090314 in limiting ectopic deposition of fat in human muscles, we combined a poly-ethylene-glycol-fibrinogen...
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Includes: Supplementary data
Journal Articles

Characterization of high- and low-risk hepatocellular adenomas by magnetic resonance imaging in an animal model of glycogen storage disease type 1A

In collection:
Cancer , Rare Disease Translational Research
Roberta Resaz, Francesca Rosa, Federica Grillo, Luca Basso, Daniela Segalerba, Andrea Puglisi, Maria Carla Bosco, Luca Mastracci, Carlo E. Neumaier, Luigi Varesio, Alessandra Eva
Journal: Disease Models & Mechanisms
Dis Model Mech (2019) 12 (4): dmm038026.
https://doi.org/10.1242/dmm.038026
Published: 5 April 2019
... and malignant transformation to hepatocellular carcinoma (HCC). Among the various subtypes of HCA, the β-catenin-activated subtype (bHCA) is associated with greatest risk of malignant transformation. Magnetic resonance imaging (MRI) is an important tool to differentiate benign and malignant hepatic lesions...
View article titled, Characterization of high- and low-risk hepatocellular adenomas by magnetic resonance imaging in an animal model of glycogen storage disease type 1A
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