Summary: DMM announces changes to its Senior Editor team and thanks its many reviewers.
Summary: Raising standards for carrying out and reporting mouse model studies will improve reproducibility and relevance to human disease research.
Summary: This article reviews the similarities between embryogenesis and cancer progression and discusses how the concepts and techniques of developmental biology are being applied to provide insight into all aspects of tumorigenesis.
Summary: The short-lived African turquoise killifish is an emerging experimental vertebrate model organism, ideal for studies aimed at discovering the basic mechanisms underlying vertebrate ageing and adult phenotypes.
Editors' choice: This study demonstrates the utility of a transgenic mouse model of breast cancer to define mechanisms of resistance to a pan-HER family inhibitor and identifies a link with EMT.
Inhibition of signaling between human CXCR4 and zebrafish ligands by the small molecule IT1t impairs the formation of triple-negative breast cancer early metastases in a zebrafish xenograft model
Summary: CXCR4-expressing human tumor cells respond to zebrafish cognate ligands and initiate metastatic events in a zebrafish xenograft model. The CXCR4 antagonist IT1t has promising tumor inhibitory effects.
Summary: Live imaging in the medaka, a popular fish model for human bone research, shows that osteoclast inhibition by bisphosphonates triggers an efficient repair of bone defects by redistributed osteoblasts.
ER stress and basement membrane defects combine to cause glomerular and tubular renal disease resulting from Col4a1 mutations in mice
Summary: Structural and compositional basement membrane defects and ER stress due to Col4a1 mutations cause glomerular and tubular kidney disease, and indicate cell-type-specific disease mechanisms for collagen diseases.
A new gestational diabetes mellitus model: hyperglycemia-induced eye malformation via inhibition of Pax6 in the chick embryo
Summary: Hyperglycemia inhibited Pax6 via oxidative stress and impaired eye development in the chick embryo, a new gestational diabetes mellitus model.
Innate immune responses to gut microbiota differ between oceanic and freshwater threespine stickleback populations
Summary: We developed a gnotobiotic threespine stickleback system to identify the cellular and genetic bases for variation in inflammatory responses to microbiota.
Standardized orthotopic xenografts in zebrafish reveal glioma cell-line-specific characteristics and tumor cell heterogeneity
Summary: This zebrafish xenotransplant model of glioblastoma enables in vivo imaging of tumor cells and rapid screening for anti-glioma agents. It provides standardization of a model that is easily replicated across laboratories.
Generation of brain tumours in mice by Cre-mediated recombination of neural progenitors in situ with the tamoxifen metabolite endoxifen
Summary: An active tamoxifen derivative can be used for the in vivo induction of recombination in situ in mice by CreERT2. We show how this method can be used to generate brain tumours through recombination of tumour suppressor genes in the subventricular zone.
Pulmonary transcriptome analysis in the surgically induced rabbit model of diaphragmatic hernia treated with fetal tracheal occlusion
Summary: Rabbit fetuses with induced diaphragmatic hernia and treated with prenatal tracheal occlusion have a similar pulmonary transcriptome as unaffected controls. This study describes a valuable database of gene expressions in this model.