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Close ModalCover: The African turquoise killifish is an extremely short-lived and rapidly ageing vertebrate with the potential to become a powerful model system to study the biology of ageing. These fish rapidly reach sexual maturation (by 4 weeks of age), and within 4 months develop cancer, undergo neurodegeneration, develop learning deficits and progressively lose fecundity. The image shows the colourful tails of two healthy adult male individuals, characterised by a typical terminal colour flag. During the ageing process, fish colour loses intensity and the tail pattern fades away. In the Review, the authors discuss the features that make this species a promising new model system. See article by Kim et al. on page 115.
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DMM Journal Meeting 2023: Infectious Diseases Through an Evolutionary Lens
We are delighted to announce that our 2023 Journal Meeting ‘Infectious Diseases Through an Evolutionary Lens’ will be held from 17-19 October 2023 in London, UK. Find out more and register your interest here.
A multi-omics approach provides insight into DUX4-induced stresses
Facioscapulohumeral muscular dystrophy is caused by misexpression of the DUX4 transcription factor. Christopher Brennan et al. take a multi-omics approach to show that MAP kinase pathways are activated in response to DUX4 expression and that this contributes to DUX4-mediated cell death.
COVID-19’s next top model
Jeong and colleagues infect K18-hACE2 mice and Syrian golden hamsters with SARS-CoV-2 to obtain comprehensive insights into COVID-19 pathogenicity in these preclinical models. This article has been highlighted as our Editor’s Choice.
Apply for a DMM Conference Travel Grant
Aimed at early-career researchers wanting to attend in-person and virtual meetings, the next application deadline for a DMM Conference Travel Grant is 3 March 2023. Find out more and hear from past recipients about their experience of the grant.
The future of model organism research
We recently published a series of articles that consider how researchers can best leverage model organisms to improve our understanding of human health and disease. You can find a summary with links to the individual articles here.
