Issues
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Cover image
Cover Image
Cover: High HDAC9 expression is associated with B cell malignancies and the article by Gil et al. on page 1483 suggests that deregulation of this epigenetic modifier can promote lymphoproliferative disease and lymphoma. Impaired p53 tumor suppressor activity in this mouse model is thought to be an important factor in disease development. Immunofluorescence analysis of spleen sections using antibodies against total p53 (top left, green) and acetylated p53 (top right, green) in wild-type control mice compared with total p53 (bottom left, green) and acetylated p53 (bottom right, green) in mice expressing transgenic histone deacetylase 9 (HDAC9) in the B cell lineage. Both wild-type endogenous and transgenic HDAC9 are stained red. Image provided by Louise Howell and licenced under a Creative Commons Attribution 4.0 International licence.
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REVIEW
Renal disease pathophysiology and treatment: contributions from the rat
Summary: This Review highlights the key role that the rat continues to play in improving our understanding of the etiologies of renal pathologies, and how these insights have opened up new therapeutic avenues.
RESEARCH ARTICLES
Heterotypic mouse models of canine osteosarcoma recapitulate tumor heterogeneity and biological behavior
Editors' choice: We developed a system that recapitulates the heterogeneous biological behavior of bone cancer in mouse models and describe novel methods to study tumor–stromal interactions in these models.
Whole-genome sequence, SNP chips and pedigree structure: building demographic profiles in domestic dog breeds to optimize genetic-trait mapping
Summary: Successful application of whole-genome sequencing and genome-wide association studies for identifying both loci and mutations in canines is influenced by breed structure and demography, motivating researchers to generate breed-specific strategies for canine genetic studies.
Lurbinectedin induces depletion of tumor-associated macrophages, an essential component of its in vivo synergism with gemcitabine, in pancreatic adenocarcinoma mouse models
Summary: Lurbinectedin-gemcitabine synergism in PDA models involves lurbinectedin-induced tumor macrophage depletion, triggering CDA downregulation and enhanced DNA damage, supporting the use of this combination to treat macrophage-infiltrated pancreatic tumors.
Helicobacter pylori VacA, acting through receptor protein tyrosine phosphatase α, is crucial for CagA phosphorylation in human duodenum carcinoma cell line AZ-521
Summary: The authors show a newly identified role of VacA in Helicobacter pylori infection through induction of tyrosine phosphorylation of CagA acting through the VacA receptor RPTPα.
Deregulated expression of HDAC9 in B cells promotes development of lymphoproliferative disease and lymphoma in mice
Summary: This study demonstrates that aberrant expression of HDAC9 in B cells promotes development of lymphoproliferative disease and lymphoma through altering expression of genes involved in the cell cycle and survival, and modulating the activity of key B-lineage factors such as BCL6 and p53.
Microglia activation in a pediatric rabbit model of tuberculous meningitis
Summary: A clinically relevant novel rabbit model provides robust microglial activation and neurological deficits as seen in children with pediatric central nervous system tuberculosis.
Recovery of erectile function comparing autologous nerve grafts, unseeded conduits, Schwann-cell-seeded guidance tubes and GDNF-overexpressing Schwann cell grafts
Summary: Schwann-cell-seeded scaffolds and GDNF-overexpressing Schwann cell grafts are superior to unseeded tubes and autologous nerve grafts for the repair of erectile nerve gaps following nerve excision in rats.
RETRACTION
DMM Journal Meeting 2024: Pre-clinical Modelling of Human Genetic Disease and Therapy

Registration is now open for our 2024 Journal Meeting. Rapid advances in gene editing and genetic technologies have revolutionised our ability to model human genetic disease and provided new hope for gene therapies. At this Meeting, we will present the very latest advances in modelling human genetic disease.
Moving towards heart success – Disease Models & Mechanisms Special Issue

DMM's most recent special issue compiles articles that aim to move heart failure to heart success by fundamentally addressing the roots of failure to identify curative strategies.
Crossroads in Virology

Our October Editorial written by Sumana Sanyal emphasises the urgency of a concerted effort in understanding virus–host interactions to inform the development of therapeutics and vaccines, helping to predict disease outcomes. Read the full Editorial here.
A Model for Life - an interview with Professor Kiran Musunuru




Read our new A Model for Life interview with Kiran Musunuru. Prof Musunuru investigates the mechanisms of disease in model systems, with the ultimate goal of developing innovative gene editing therapies.
Sustainable Conferencing Initiative

Through our Sustainable Conferencing Grants, we promote the use of new technology and greener modes of travel. Our blog posts showcase examples of sustainability in action and share experience about how new technologies and conference formats work in practice.