Summary: Philanthropists and scientists share many common interests, and yet they are not familiar with each other's ways of thinking. This Editorial highlights how to improve their mutual understanding to advance research and life sciences.
Summary: This paper reviews recent data on Diamond Blackfan anemia and discusses them in connection with other ribosomopathies.
Auditory hair cell defects as potential cause for sensorineural deafness in Wolf-Hirschhorn syndrome
Editor’s Choice: WHS is associated with sensorineural deafness. Here, the authors show that, although cochlear hair cells are specified normally in a WHS mouse model, they are disorganised and display sterocilia defects.
Summary: This study provides clinical and experimental evidence for the different roles played by excess calorie intake in the development of NAFLD and fibrosis; these diseases are dependent on age and reproductive status.
Huntington disease iPSCs show early molecular changes in intracellular signaling, the expression of oxidative stress proteins and the p53 pathway
Summary: This research demonstrates that dysregulation of signaling pathways is a very early event in the pathogenesis of Huntington disease and that these pathways are already dysregulated in cells at the stage of pluripotency.
The role of mTOR signaling in the regulation of protein synthesis and muscle mass during immobilization in mice
Summary: The activation of mTOR signaling is both necessary and sufficient to alleviate the decreases in protein synthesis and muscle mass that occur during immobilization.
Acute perioperative-stress-induced increase of atherosclerotic plaque volume and vulnerability to rupture in apolipoprotein-E-deficient mice is amenable to statin treatment and IL-6 inhibition
Summary: We developed a model to study the dynamics of atherosclerotic plaque growth and stability following surgery, and show that IL-6 inhibition and statins beneficially affect plaque volume and complexity.
Summary: These findings demonstrate that Fos is a direct target of miR-146a activity and that downregulation of the Fos–AP-1 pathway by miR-146a can inhibit MMP-9 activity.
Summary: HIF1α deficiency reduces inflammation in the mouse proximal colon but is associated with defective E-cadherin expression in colon epithelial cells when mice lacking intestinal epithelium expression of Hif1α are challenged with sulindac.
Suppression of β3-integrin in mice triggers a neuropilin-1-dependent change in focal adhesion remodelling that can be targeted to block pathological angiogenesis
Summary: Targeting both β3-integrin and neuropilin-1 prevents anti-angiogenic treatment escape.
Scaffold attachment factor B2 (SAFB2)-null mice reveal non-redundant functions of SAFB2 compared with its paralog, SAFB1
Summary: Analysis of SAFB2−/− mice reveals lack of redundancy between the closely related paralogs SAFB1 and SAFB2, and a role for SAFB2 in the male reproductive system, specifically in Sertoli cells.
The anti-fibrotic effect of inhibition of TGFβ-ALK5 signalling in experimental pulmonary fibrosis in mice is attenuated in the presence of concurrent γ-herpesvirus infection
Summary: This article describes newly identified intricacies for the TGFβ-ALK5 signalling axis in experimental lung fibrosis and reports different outcomes in response to ALK5 inhibition depending on the presence of viral infection. These findings raise important considerations for the future targeting of TGFβ signalling responses in the context of pulmonary fibrosis.
Lung necrosis and neutrophils reflect common pathways of susceptibility to Mycobacterium tuberculosis in genetically diverse, immune-competent mice
Summary: Molecular biomarkers of tuberculosis are identified and used to classify disease status of Diversity Outbred mice that have been infected with Mycobacterium tuberculosis.
The generation and characterization of novel Col1a1FRT-Cre-ER-T2-FRT and Col1a1FRT-STOP-FRT-Cre-ER-T2 mice for sequential mutagenesis
Summary: We generated two mouse strains expressing Cre-ERT2 under Flp-FRT regulation. These tools enable sequential mutagenesis in the same or different cells to study development, tissue homeostasis and diseases such as cancer.