Issues
-
Cover image
Cover Image
Cover: Mitochondria (green) in Drosophila ovarian germ cells form abnormal large clumps in the absence of the highly conserved protein Clueless. See article by Sen et al. on page 577.
- PDF Icon PDF LinkTable of contents
- PDF Icon PDF LinkIssue info
IN THIS ISSUE
REVIEW
Yeast as a system for modeling mitochondrial disease mechanisms and discovering therapies
Summary: In this Review, we discuss the use of budding yeast to understand mitochondrial diseases and help in the search for their treatments.
RESEARCH ARTICLES
The Meckel-Gruber syndrome protein TMEM67 controls basal body positioning and epithelial branching morphogenesis in mice via the non-canonical Wnt pathway
Highlighted Article: TMEM67 is a receptor of non-canonical Wnt signalling, implicating the Wnt5a-TMEM67-ROR2 axis during developmental signalling and disruption in ciliopathy disease state.
The lysyl oxidase inhibitor β-aminopropionitrile reduces body weight gain and improves the metabolic profile in diet-induced obesity in rats
Highlighted Article: Lysyl oxidase (LOX) could play a role in the metabolic dysfunction induced by obesity, and consequently the inhibition of LOX activity could be a valuable strategy to ameliorate obesity-related metabolic disturbances.
High-resolution live imaging reveals axon-glia interactions during peripheral nerve injury and repair in zebrafish
Summary: Schwann cells are important components of the peripheral glia. We use microsurgery and high-resolution live imaging to show how Schwann cells control the regeneration of a sensorineural circuit.
Phenotype-driven chemical screening in zebrafish for compounds that inhibit collective cell migration identifies multiple pathways potentially involved in metastatic invasion
Summary: We have developed a phenotype-driven screen for identifying new inhibitors of collective cell migration and demonstrated the screen can successfully identify compounds active in vivo and potentially new pathways for targeting cancer metastasis.
Clueless, a protein required for mitochondrial function, interacts with the PINK1-Parkin complex in Drosophila
Summary: The protein Clueless is crucial for mitochondrial function and can interact genetically and physically with the PINK1-Parkin mitophagy complex.
Presence of multiple lesion types with vastly different microenvironments in C3HeB/FeJ mice following aerosol infection with Mycobacterium tuberculosis
Summary: C3HeB/FeJ mice develop three morphologically distinct lesion types, which differ with respect to bacterial load, cellular composition and degree of immunopathology following low-dose aerosol infection with Mycobacterium tuberculosis.
Heterogeneous disease progression and treatment response in a C3HeB/FeJ mouse model of tuberculosis
Summary: C3HeB/FeJ mice develop a wide range of lesion types that alter drug response in a way that might better inform tuberculosis drug development.
Understanding the molecular mechanisms of human microtia via a pig model of HOXA1 syndrome
Summary: A pig model of HOXA1 syndrome provides novel insight into the molecular mechanisms of human microtia.
Deletion of the App-Runx1 region in mice models human partial monosomy 21
Summary: The Del(16App-Runx1)5Yah mouse model displays morphological abnormalities and behavioural phenotypes similar to those found in humans with partial monosomy 21, and it therefore demonstrates the major contribution of the App-Runx1 region to the pathophysiology of partial monosomy 21.
RESOURCE ARTICLE
Leiomodin-3-deficient mice display nemaline myopathy with fast-myofiber atrophy
Highlighted Article: A leiomodin-3 mouse mutant generated by insertion of the piggyBac transposon exhibits nemaline myopathy with fast-myofiber-specific atrophy.
History of our journals
As our publisher, The Company of Biologists, turns 100 years old, read about DMM’s history and explore the journey of each of our sister journals: Development, Journal of Cell Science, Journal of Experimental Biology and Biology Open.
A new perspective on disease research
DMM publishes perspectives – peer-reviewed articles that provide expert analysis of a topic important to the disease research community. Read our collection from authors presenting new or potentially controversial ideas or hypotheses, to help address future challenges and forge new directions.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.
