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Volume 8, Issue 1
January 2015
Disease Models & Mechanisms Cover Image for Volume 8, Issue 1
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  • Cover image

    Cover Image

    issue cover
    Cover: X-ray image of the hands from a patient with hand osteoarthritis. Both proximal and distal interphalangeal joints are affected, with loss of cartilage (visible as loss of joint space) and joint remodelling. These radiographic signs are typically accompanied by joint pain, swelling and stiffness. See Review article by Thysen et al. on page 17.
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ISSN 1754-8403
EISSN 1754-8411
In this issue

IN THIS ISSUE

Insights into orofacial birth defects
View articletitled, Insights into orofacial birth defects
A preclinical model of glioblastoma
View articletitled, A preclinical model of glioblastoma

SPECIAL ARTICLE

How informative is the mouse for human gut microbiota research?
Thi Loan Anh Nguyen,Sara Vieira-Silva,Adrian Liston,Jeroen Raes
View articletitled, How informative is the mouse for human gut microbiota research?
Supplementary information
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REVIEW

Targets, models and challenges in osteoarthritis research
Sarah Thysen,Frank P. Luyten,Rik J. U. Lories
View articletitled, Targets, models and challenges in osteoarthritis research
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RESEARCH ARTICLES

Tfap2a-dependent changes in mouse facial morphology result in clefting that can be ameliorated by a reduction in Fgf8 gene dosage
Rebecca M. Green,Weiguo Feng,Tzulip Phang,Jennifer L. Fish,Hong Li,Richard A. Spritz,Ralph S. Marcucio,Joan Hooper,Heather Jamniczky,Benedikt Hallgrímsson,Trevor Williams
View articletitled, <em>Tfap2a</em>-dependent changes in mouse facial morphology result in clefting that can be ameliorated by a reduction in <em>Fgf8</em> gene dosage
Supplementary information
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A preclinical orthotopic model for glioblastoma recapitulates key features of human tumors and demonstrates sensitivity to a combination of MEK and PI3K pathway inhibitors
Rajaa El Meskini,Anthony J. Iacovelli,Alan Kulaga,Michelle Gumprecht,Philip L. Martin,Maureen Baran,Deborah B. Householder,Terry Van Dyke,Zoë Weaver Ohler
View articletitled, A preclinical orthotopic model for glioblastoma recapitulates key features of human tumors and demonstrates sensitivity to a combination of MEK and PI3K pathway inhibitors
Supplementary information
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Untangling dopamine-adenosine receptor-receptor assembly in experimental parkinsonism in rats
Víctor Fernández-Dueñas,Jaume J. Taura,Martin Cottet,Maricel Gómez-Soler,Marc López-Cano,Catherine Ledent,Masahiko Watanabe,Eric Trinquet,Jean-Philippe Pin,Rafael Luján,Thierry Durroux,Francisco Ciruela
View articletitled, Untangling dopamine-adenosine receptor-receptor assembly in experimental parkinsonism in rats
Supplementary information
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Upregulation of CREM/ICER suppresses wound endothelial CRE-HIF-1α-VEGF-dependent signaling and impairs angiogenesis in type 2 diabetes
Milad S. Bitar,Fahd Al-Mulla
View articletitled, Upregulation of CREM/ICER suppresses wound endothelial CRE-HIF-1α-VEGF-dependent signaling and impairs angiogenesis in type 2 diabetes
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A Drosophila XPD model links cell cycle coordination with neuro-development and suggests links to cancer
Karin Stettler,Xiaoming Li,Björn Sandrock,Sophie Braga-Lagache,Manfred Heller,Lutz Dümbgen,Beat Suter
View articletitled, A <em>Drosophila</em> XPD model links cell cycle coordination with neuro-development and suggests links to cancer
Supplementary information
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The impact of low-magnitude high-frequency vibration on fracture healing is profoundly influenced by the oestrogen status in mice
Esther Wehrle,Astrid Liedert,Aline Heilmann,Tim Wehner,Ronny Bindl,Lena Fischer,Melanie Haffner-Luntzer,Franz Jakob,Thorsten Schinke,Michael Amling,Anita Ignatius
View articletitled, The impact of low-magnitude high-frequency vibration on fracture healing is profoundly influenced by the oestrogen status in mice
Supplementary information
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Accepted manuscripts
Glucose uptake in pigment glia suppresses tau-induced inflammation and photoreceptor degeneration in Drosophila
Mikiko Oka, Sho Nakajima, Emiko Suzuki, Shinya Yamamoto, Kanae Ando
Patient-specific mutation of a contact site protein Tomm70 causes neurodegeneration in a zebrafish model
Vranda Garg, Ralf Heinrich, Roshan Priyarangana Perera, Till Ischebeck, Wiebke Möbius, Torben Ruhwedel, Patricia Scholz, Gabriela Salinas, Christian Dullin, Martin C. Göpfert, Jacob Engelmann, Roland Dosch, Bart R. H. Geurten
Anatomical and functional studies of isolated vestibular neuroepithelia from Ménière's Disease patients
Hannah R. Drury, Melissa A. Tadros, Robert J. Callister, Alan M. Brichta, Robert Eisenberg, Rebecca Lim
Microvascular aberrations found in human polycystic kidneys are an early feature in a Pkd1 mutant mouse model
Daniyal J. Jafree, Charith Perera, Mary Ball, Daniele Tolomeo, Gideon Pomeranz, Laura Wilson, Benjamin Davis, William J. Mason, Eva Maria Funk, Maria Kolatsi-Joannou, Radu Polschi, Saif Malik, Benjamin J. Stewart, Karen L. Price, Hannah Mitchell, Reza Motallebzadeh, Yoshiharu Muto, Robert Lees, Sarah Needham, Dale Moulding, Jennie C. Chandler, Sonal Nandanwar, Claire L. Walsh, Paul J. D. Winyard, Peter J. Scambler, René Hägerling, Menna R. Clatworthy, Benjamin D. Humphreys, Mark F. Lythgoe, Simon Walker-Samuel, Adrian S. Woolf, David A. Long
CIB2 function is distinct from Whirlin in the development of cochlear stereocilia staircase pattern
Arnaud P. J. Giese, Andrew Parker, Sakina Rehman, Steve D. M. Brown, Saima Riazuddin, Craig W. Vander Kooi, Michael R. Bowl, Zubair M. Ahmed
More accepted manuscripts

History of our journals

As our publisher, The Company of Biologists, turns 100 years old, read about DMM’s history and explore the journey of each of our sister journals: Development, Journal of Cell Science, Journal of Experimental Biology and Biology Open.

A new perspective on disease research

DMM publishes perspectives – peer-reviewed articles that provide expert analysis of a topic important to the disease research community. Read our collection from authors presenting new or potentially controversial ideas or hypotheses, to help address future challenges and forge new directions.

Read & Publish Open Access publishing: what authors say

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We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.

About us

Our publisher, The Company of Biologists, turns 100 this year. Read about the history of the Company and find out what Sarah Bray, our Chair of the Board of Directors, has to say.

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