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Volume 7, Issue 9
September 2014
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    Cover: Persistent inflammation underlies many disease processes. At present, there is an unmet need for new alternative therapeutic approaches to treat inflammation. Drug repositioning is the process of ‘recycling’ existing drugs for new therapeutic uses. The zebrafish model is a well-established system in which to investigate the inflammatory response and is a powerful drug discovery platform. Arraying embryos into multi-well plates (as pictured) and assessing the effects of known drugs on the recruitment of neutrophils during wound healing revealed unknown anti-inflammatory activities for a number of drugs that were validated in mammals.
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ISSN 1754-8403
EISSN 1754-8411
In this issue

IN THIS ISSUE

Insights into granuloma formation in tuberculous meningitis using the zebrafish-M. marinum model
View articletitled, Insights into granuloma formation in tuberculous meningitis using the zebrafish-<em>M. marinum</em> model
Tackling the respiratory abnormalities of Rett syndrome
View articletitled, Tackling the respiratory abnormalities of Rett syndrome
A mouse model for neonatal jaundice
View articletitled, A mouse model for neonatal jaundice

REVIEWS

Interplay between sirtuins, MYC and hypoxia-inducible factor in cancer-associated metabolic reprogramming
Bernadette M. M. Zwaans,David B. Lombard
View articletitled, Interplay between sirtuins, MYC and hypoxia-inducible factor in cancer-associated metabolic reprogramming
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Linking susceptibility genes and pathogenesis mechanisms using mouse models of systemic lupus erythematosus
Steve P. Crampton,Peter A. Morawski,Silvia Bolland
View articletitled, Linking susceptibility genes and pathogenesis mechanisms using mouse models of systemic lupus erythematosus
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RESEARCH ARTICLES

A BDNF loop-domain mimetic acutely reverses spontaneous apneas and respiratory abnormalities during behavioral arousal in a mouse model of Rett syndrome
Miriam Kron,Min Lang,Ian T. Adams,Michael Sceniak,Frank Longo,David M. Katz
View articletitled, A BDNF loop-domain mimetic acutely reverses spontaneous apneas and respiratory abnormalities during behavioral arousal in a mouse model of Rett syndrome
Supplementary information
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Age-dependent pattern of cerebellar susceptibility to bilirubin neurotoxicity in vivo in mice
Giulia Bortolussi,Gabriele Baj,Simone Vodret,Giulia Viviani,Tamara Bittolo,Andrés F. Muro
View articletitled, Age-dependent pattern of cerebellar susceptibility to bilirubin neurotoxicity <em>in vivo</em> in mice
Supplementary information
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Repositioning drugs for inflammatory disease – fishing for new anti-inflammatory agents
Christopher J. Hall,Sophie M. Wicker,An-Tzu Chien,Alisha Tromp,Lisa M. Lawrence,Xueying Sun,Geoffrey W. Krissansen,Kathryn E. Crosier,Philip S. Crosier
View articletitled, Repositioning drugs for inflammatory disease – fishing for new anti-inflammatory agents
Supplementary information
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Development of hepatocellular adenomas and carcinomas in mice with liver-specific G6Pase-α deficiency
Roberta Resaz,Cristina Vanni,Daniela Segalerba,Angela R. Sementa,Luca Mastracci,Federica Grillo,Daniele Murgia,Maria Carla Bosco,Janice Y. Chou,Ottavia Barbieri,Luigi Varesio,Alessandra Eva
View articletitled, Development of hepatocellular adenomas and carcinomas in mice with liver-specific G6Pase-α deficiency
Supplementary information
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In vivo siRNA delivery of Keap1 modulates death and survival signaling pathways and attenuates concanavalin-A-induced acute liver injury in mice
Águeda González-Rodríguez,Bjorn Reibert,Thomas Amann,Rainier Constien,Cristina M. Rondinone,Ángela M. Valverde
View articletitled, <em>In vivo</em> siRNA delivery of <em>Keap1</em> modulates death and survival signaling pathways and attenuates concanavalin-A-induced acute liver injury in mice
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Spinal cord pathology is ameliorated by P2X7 antagonism in a SOD1-mutant mouse model of amyotrophic lateral sclerosis
Savina Apolloni,Susanna Amadio,Chiara Parisi,Alessandra Matteucci,Rosa L. Potenza,Monica Armida,Patrizia Popoli,Nadia D’Ambrosi,Cinzia Volonté
View articletitled, Spinal cord pathology is ameliorated by P2X7 antagonism in a SOD1-mutant mouse model of amyotrophic lateral sclerosis
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RESOURCE ARTICLES

Modeling tuberculous meningitis in zebrafish using Mycobacterium marinum
Lisanne M. van Leeuwen,Martijn van der Kuip,Sameh A. Youssef,Alain de Bruin,Wilbert Bitter,A. Marceline van Furth,Astrid M. van der Sar
View articletitled, Modeling tuberculous meningitis in zebrafish using <em>Mycobacterium marinum</em>
Supplementary information
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Robust circadian rhythms in organoid cultures from PERIOD2::LUCIFERASE mouse small intestine
Sean R. Moore,Jill Pruszka,Jefferson Vallance,Eitaro Aihara,Toru Matsuura,Marshall H. Montrose,Noah F. Shroyer,Christian I. Hong
View articletitled, Robust circadian rhythms in organoid cultures from PERIOD2::LUCIFERASE mouse small intestine
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Accepted manuscripts
Anatomical and functional studies of isolated vestibular neuroepithelia from Ménière's Disease patients
Hannah R. Drury, Melissa A. Tadros, Robert J. Callister, Alan M. Brichta, Robert Eisenberg, Rebecca Lim
Microvascular aberrations found in human polycystic kidneys are an early feature in a Pkd1 mutant mouse model
Daniyal J. Jafree, Charith Perera, Mary Ball, Daniele Tolomeo, Gideon Pomeranz, Laura Wilson, Benjamin Davis, William J. Mason, Eva Maria Funk, Maria Kolatsi-Joannou, Radu Polschi, Saif Malik, Benjamin J. Stewart, Karen L. Price, Hannah Mitchell, Reza Motallebzadeh, Yoshiharu Muto, Robert Lees, Sarah Needham, Dale Moulding, Jennie C. Chandler, Sonal Nandanwar, Claire L. Walsh, Paul J. D. Winyard, Peter J. Scambler, René Hägerling, Menna R. Clatworthy, Benjamin D. Humphreys, Mark F. Lythgoe, Simon Walker-Samuel, Adrian S. Woolf, David A. Long
CIB2 function is distinct from Whirlin in the development of cochlear stereocilia staircase pattern
Arnaud P. J. Giese, Andrew Parker, Sakina Rehman, Steve D. M. Brown, Saima Riazuddin, Craig W. Vander Kooi, Michael R. Bowl, Zubair M. Ahmed
Reduced growth and biofilm formation at high temperatures contribute to Cryptococcus deneoformans dermatotropism
Claudia L. Charles-Nino, Gunjan M. Desai, Nicholas Koroneos, Mohamed F. Hamed, Neena Jain, William Lopes, Anthony Braswell, Alexander Linares, Melissa E. Munzen, Joshua D. Nosanchuk, Marilene H. Vainstein, Luis R. Martinez
Mutations in the Bone Morphogenetic Protein signaling pathway sensitize zebrafish and humans to ethanol-induced jaw malformations
John R. Klem, Tae-Hwi Schwantes-An, Marco Abreu, Michael Suttie, Raeden Gray, Hieu Vo, Grace Conley, Tatiana M. Foroud, Leah Wetherill, CIFASD, C. Ben Lovely
More accepted manuscripts

History of our journals

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