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Volume 7, Issue 8
August 2014
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    Cover Image

    issue cover
    Cover: The vasopressin receptor is an important modulator of behaviour, and differences in the temporal and spatial expression of the receptor underlie species differences, including those between monogamous and polygamous voles. The figure shows vasopressin binding to normal mouse brain (left), to mouse brain expressing the human vasopressin receptor gene and the mouse gene (middle), and to mouse brain expressing only the human gene. The profound differences in expression with the human receptor parallel those seen in primate and human studies.
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ISSN 1754-8403
EISSN 1754-8411

IN THIS ISSUE

Repurposing of an immunosuppressive drug holds promise for stem-cell-based neurorepair
View articletitled, Repurposing of an immunosuppressive drug holds promise for stem-cell-based neurorepair
Hypothermia: a cool therapeutic approach for AD-HSP?
View articletitled, Hypothermia: a cool therapeutic approach for AD-HSP?
Notch signalling restores satellite stem cell activity in a model of DMD
View articletitled, Notch signalling restores satellite stem cell activity in a model of DMD

A MODEL FOR LIFE

Translating the molecular hallmarks of colorectal cancer to patient therapies: an interview with Owen Sansom

Owen Sansom, Deputy Director of the Cancer Research UK Beatson Institute, began his research career investigating the molecular mechanisms of apoptosis. Over the course of his work he has moved progressively into a more translational arena, and the current focus of his lab is to understand the signalling pathways underlying colorectal and pancreatic cancers. The Sansom lab uses mouse models to pinpoint how mutations that commonly occur in these frequently deadly cancers co-operate to promote tumorigenesis in vivo. This work has provided many important insights into the molecular changes associated with intestinal and pancreatic neoplasia and has revealed new targets for drug development. Here, Owen tells the stories behind some of his most exciting breakthroughs, describes the experiences and mentors that shaped his research interests and style of running a lab, and discusses the challenges of recapitulating the complexity of cancer as well as translating preclinical evidence to patient therapies.

View articletitled, Translating the molecular hallmarks of colorectal cancer to patient therapies: an interview with Owen Sansom
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REVIEW

Acute myeloid leukaemia: a paradigm for the clonal evolution of cancer?
Carolyn S. Grove,George S. Vassiliou
View articletitled, Acute myeloid leukaemia: a paradigm for the clonal evolution of cancer?
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RESEARCH ARTICLES

Cyclosporin A enhances neural precursor cell survival in mice through a calcineurin-independent pathway
Nadia Sachewsky,Jessica Hunt,Michael J. Cooke,Ashkan Azimi,Taraneh Zarin,Carween Miu,Molly S. Shoichet,Cindi M. Morshead
View articletitled, Cyclosporin A enhances neural precursor cell survival in mice through a calcineurin-independent pathway
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A novel mouse model for inhibition of DOHH-mediated hypusine modification reveals a crucial function in embryonic development, proliferation and oncogenic transformation
Henning Sievert,Nora Pällmann,Katharine K. Miller,Irm Hermans-Borgmeyer,Simone Venz,Ataman Sendoel,Michael Preukschas,Michaela Schweizer,Steffen Boettcher,P. Christoph Janiesch,Thomas Streichert,Reinhard Walther,Michael O. Hengartner,Markus G. Manz,Tim H. Brümmendorf,Carsten Bokemeyer,Melanie Braig,Joachim Hauber,Kent E. Duncan,Stefan Balabanov
View articletitled, A novel mouse model for inhibition of DOHH-mediated hypusine modification reveals a crucial function in embryonic development, proliferation and oncogenic transformation
Supplementary information
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Insulin-like growth factor-1 induces regulatory T cell-mediated suppression of allergic contact dermatitis in mice
Bjarki Johannesson,Susanne Sattler,Ekaterina Semenova,Saveria Pastore,Teresa M. Kennedy-Lydon,Robert D. Sampson,Michael D. Schneider,Nadia Rosenthal,Daniel Bilbao
View articletitled, Insulin-like growth factor-1 induces regulatory T cell-mediated suppression of allergic contact dermatitis in mice
Supplementary information
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TGF-β mediates early angiogenesis and latent fibrosis in an Emilin1-deficient mouse model of aortic valve disease
Charu Munjal,Amy M. Opoka,Hanna Osinska,Jeanne F. James,Giorgio M. Bressan,Robert B. Hinton
View articletitled, TGF-β mediates early angiogenesis and latent fibrosis in an Emilin1-deficient mouse model of aortic valve disease
Supplementary information
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RESEARCH REPORTS

Notch signaling deficiency underlies age-dependent depletion of satellite cells in muscular dystrophy
Chunhui Jiang,Yefei Wen,Kazuki Kuroda,Kevin Hannon,Michael A. Rudnicki,Shihuan Kuang
View articletitled, Notch signaling deficiency underlies age-dependent depletion of satellite cells in muscular dystrophy
Supplementary information
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Cold temperature improves mobility and survival in Drosophila models of autosomal-dominant hereditary spastic paraplegia (AD-HSP)
Sally L. Baxter,Denise E. Allard,Christopher Crowl,Nina Tang Sherwood
View articletitled, Cold temperature improves mobility and survival in <em>Drosophila</em> models of autosomal-dominant hereditary spastic paraplegia (AD-HSP)
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RESOURCE ARTICLE

Introduction of the human AVPR1A gene substantially alters brain receptor expression patterns and enhances aspects of social behavior in transgenic mice
Rhonda Charles,Takeshi Sakurai,Nagahide Takahashi,Gregory A. Elder,Miguel A. Gama Sosa,Larry J. Young,Joseph D. Buxbaum
View articletitled, Introduction of the human <em>AVPR1A</em> gene substantially alters brain receptor expression patterns and enhances aspects of social behavior in transgenic mice
Supplementary information
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Accepted manuscripts
Abca4, mutated in Stargardt Disease, is required for cone outer segment structural integrity
John J. Willoughby, Abbie M. Jensen
Slc26a2-mediated sulfate metabolism is significant for the tooth development
Y. Yoshida, T. Inubushi, M. Yokoyama, P. Nag, J. I. Sasaki, A. Oka, T. Murotani, R. Kani, Y. Shiraishi, H. Kurosaka, Y. Takahata, R. Nishimura, S. Imazato, P. Papagerakis, T. Yamashiro
The role of mesenchymal cells in cholangiocarcinoma
Mireia Sueca-Comes, Elena Cristina Rusu, Jennifer C. Ashworth, Pamela Collier, Catherine Probert, Alison Ritchie, Marian Meakin, Nigel P. Mongan, Isioma U. Egbuniwe, Jesper Bøje Andersen, David O. Bates, Anna M. Grabowska
Generation of a zebrafish neurofibromatosis model via inducible knockout of nf2
Ayyappa Raja Desingu Rajan, Yuanyun Huang, Jan Stundl, Katelyn Chu, Anushka Irodi, Zihan Yang, Brian E. Applegate, Marianne E. Bronner
Generation and characterization of a novel mouse model of Becker Muscular Dystrophy with a deletion of exons 52 to 55
Lucie O. M. Perillat, Tatianna W. Y. Wong, Eleonora Maino, Abdalla Ahmed, Ori Scott, Elzbieta Hyatt, Paul Delgado-Olguin, Shagana Visuvanathan, Evgueni A. Ivakine, Ronald D. Cohn
More accepted manuscripts

Call for Papers – Infectious Disease: Evolution, Mechanisms and Global Health

Showcase your latest research on our upcoming Special Issue: Infectious Disease: Evolution, Mechanisms and Global Health. This issue will be coordinated by DMM Editors Sumana Sanyal and David Tobin alongside Guest Editors Judi Allen and Russell Vance. The deadline for submitting articles to this Special Issue has been extended to Monday 24 February 2025.

Biologists @ 100 - join us in Liverpool in March 2025

We are excited to invite you to a unique scientific conference, celebrating the 100-year anniversary of The Company of Biologists, and bringing together our different communities. The conference will incorporate a DMM programme on antimicrobial resistance on 26 March 2025. Find out more and register to join us in March 2025 in Liverpool, UK.

Apply to become a reporter at the Biologists @ 100 conference

Are you keen to get more science communication experience? Is your research related to developmental and stem cell biology or microscopy? The Node and FocalPlane are looking for one reporter each to attend and report from the Biologists @ 100 conference, happening on 24-27 March 2025 in Liverpool, UK. Apply by 29 November 2024.

The role of the International Society for Stem Cell Research guidelines in disease modelling


The International Society for Stem Cell Research (ISSCR) provides comprehensive guidelines and standards for using human stem cells in biomedical research. In this Editorial, Cody Juguilon and Joseph Wu discuss how and why these should be incorporated in disease modelling research.

Read & Publish Open Access publishing: what authors say

Promotional banner for R&P agreements

We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.

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