Issues
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Cover image
Cover Image
Cover: The vasopressin receptor is an important modulator of behaviour, and differences in the temporal and spatial expression of the receptor underlie species differences, including those between monogamous and polygamous voles. The figure shows vasopressin binding to normal mouse brain (left), to mouse brain expressing the human vasopressin receptor gene and the mouse gene (middle), and to mouse brain expressing only the human gene. The profound differences in expression with the human receptor parallel those seen in primate and human studies.Close Modal - PDF Icon PDF LinkTable of contents
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IN THIS ISSUE
A MODEL FOR LIFE
Translating the molecular hallmarks of colorectal cancer to patient therapies: an interview with Owen Sansom
Owen Sansom, Deputy Director of the Cancer Research UK Beatson Institute, began his research career investigating the molecular mechanisms of apoptosis. Over the course of his work he has moved progressively into a more translational arena, and the current focus of his lab is to understand the signalling pathways underlying colorectal and pancreatic cancers. The Sansom lab uses mouse models to pinpoint how mutations that commonly occur in these frequently deadly cancers co-operate to promote tumorigenesis in vivo. This work has provided many important insights into the molecular changes associated with intestinal and pancreatic neoplasia and has revealed new targets for drug development. Here, Owen tells the stories behind some of his most exciting breakthroughs, describes the experiences and mentors that shaped his research interests and style of running a lab, and discusses the challenges of recapitulating the complexity of cancer as well as translating preclinical evidence to patient therapies.
REVIEW
RESEARCH ARTICLES
A novel mouse model for inhibition of DOHH-mediated hypusine modification reveals a crucial function in embryonic development, proliferation and oncogenic transformation
RESEARCH REPORTS
RESOURCE ARTICLE
Call for papers: Moving Heart Failure to Heart Success

Disease Models & Mechanisms is pleased to welcome submissions for consideration for an upcoming special issue, Moving Heart Failure to Heart Success: Mechanisms, Regeneration & Therapy. The deadline for submitting articles to the special issue has been extended to 1 August 2022.
Modelling interactions at the blood–brain barrier

In their Review, Yvonne Adams and Anja Ramstedt Jensen review the available in vitro models to investigate the impact of adhesion of Plasmodium falciparum-infected red blood cells on the blood–brain barrier, a process associated with cerebral malaria.
Focus on Genetic Variance in Human Disease

New technologies, computational methods and model systems are revealing how human genetic variance contributes to disease mechanisms. DMM’s new Subject Focus highlights this evolving area of research.
Apply for a DMM Conference Travel Grant

Aimed at early-career researchers wanting to attend in-person and virtual meetings, the next application deadline for a DMM Conference Travel Grant is 1 September 2022. Find out more and hear from past recipients about their experience of the grant.