Issues
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Cover image
Cover Image
Cover: Image of an Ambystoma mexicanum limb that has been stained with alizarin red (bone) and alcian blue (cartilage). An ectopic limb (right side) was induced to grow from a wound on the limb proper by deviating a severed nerve and grafting tissue from the opposite limb axis into the wound site. This assay, known as the accessory limb assay, makes it possible to test each of the critical components of limb regeneration: (1) the wound, (2) neurotrophic factors and (3) positional information. Understanding the role of each of these components during limb regeneration in the adult A. mexicanum will bring us closer to harnessing the regenerative capacity in humans. Image by Catherine McCusker from the Gardiner/Bryant research group. See article by McCusker and Gardiner on page 593. - PDF Icon PDF LinkTable of contents
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IN THIS ISSUE
REVIEW
RESEARCH ARTICLES
Cross-species analysis of genetically engineered mouse models of MAPK-driven colorectal cancer identifies hallmarks of the human disease
Cryptosporidium parvum-induced ileo-caecal adenocarcinoma and Wnt signaling in a mouse model
Balance between the two kinin receptors in the progression of experimental focal and segmental glomerulosclerosis in mice
A novel mouse model of Warburg Micro syndrome reveals roles for RAB18 in eye development and organisation of the neuronal cytoskeleton
New Special Issue: Translating Multiscale Research in Rare Disease. Edited by Monica Justice, Monkol Lek, Karen Liu and Kate Rauen.
This special issue features original Research, Resources & Methods and Review-type articles that aim to interrogate the mechanisms of rare diseases to foster meaningful clinical progress in their diagnosis and treatment.
The role of the International Society for Stem Cell Research (ISSCR) guidelines in disease modelling
The ISSCR provides comprehensive guidelines and standards for using human stem cells in biomedical research. In this Editorial, Cody Juguilon and Joseph Wu discuss how and why these should be incorporated in disease modelling research.
Subject collection: Building advocacy into research
DMM’s series - Building advocacy into research - features interviews, ‘The Patient’s Voice’, with patients and advocates for a range of disease types, with the aim of supporting the highest quality research for the benefit of all patients affected by disease.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.
Biologists @ 100 - join us in Liverpool in March 2025
We are excited to invite you to a unique scientific conference, celebrating the 100-year anniversary of The Company of Biologists, and bringing together our different communities. The conference will incorporate the Spring Meetings of the BSCB and the BSDB, the JEB Symposium Sensory Perception in a Changing World and a DMM programme on antimicrobial resistance. Find out more and register your interest to join us in March 2025 in Liverpool, UK.