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Issues

Volume 7, Issue 3
March 2014
Issue Cover
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  • Cover image

    Cover Image

    issue cover
    Cover: Staining for DNA damage in sections from prostate cancer xenograft tumours, showing immunostaining of γH2AX (red fluorescence) and overlay with DAPI as a counterstain (blue fluorescence). Strong labeling was seen with the different treatments, including with the combined treatment of ultrasound-stimulated microbubbles combined with high radiation (MB+US+8Gy), shown here. See article by Al-Mahrouki et al. on page 363.
  • PDF Icon PDF LinkTable of contents
ISSN 1754-8403
EISSN 1754-8411

In This Issue

Measuring motor deficits in mice
View articletitled, Measuring motor deficits in mice
Colorectal cancer models with increased metastasis
View articletitled, Colorectal cancer models with increased metastasis
Mouse model for chronic liver damage and fibrosis
View articletitled, Mouse model for chronic liver damage and fibrosis

Community News

Building failure into successful team science: highlights of the second SINAInnovations event
Arielle Klepper,Matthew Pendleton
View articletitled, Building failure into successful team science: highlights of the second SINA<em>Innovations</em> event
Supplementary information
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A Model For Life

Revolutionizing cancer care with next-generation sequencing: an interview with Elaine Mardis

Elaine Mardis, co-director at the Washington University Genome Institute, has a long-standing interest in the development of sequencing technologies, which, in the 1990s, led her to play a pivotal role in the completion of the Human Genome project. Driven by the desire to apply her technological know-how to the improvement of human health, she then pioneered the sequencing and analysis of cancer genomes. These milestones have established Elaine as a leader in the cancer genomics field. In this interview, she recalls the events that shaped her career path, discusses the value of industry experience in a research setting, and provides her perspectives on challenges to clinical implementation of next-generation sequencing.

View articletitled, Revolutionizing cancer care with next-generation sequencing: an interview with Elaine Mardis
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Reviews

The role of the cytosolic HSP70 chaperone system in diseases caused by misfolding and aberrant trafficking of ion channels
Jason C. Young
View articletitled, The role of the cytosolic HSP70 chaperone system in diseases caused by misfolding and aberrant trafficking of ion channels
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Glycoprotein folding and quality-control mechanisms in protein-folding diseases
Sean P. Ferris,Vamsi K. Kodali,Randal J. Kaufman
View articletitled, Glycoprotein folding and quality-control mechanisms in protein-folding diseases
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Modeling metabolic homeostasis and nutrient sensing in Drosophila: implications for aging and metabolic diseases
Edward Owusu-Ansah,Norbert Perrimon
View articletitled, Modeling metabolic homeostasis and nutrient sensing in <em>Drosophila</em>: implications for aging and metabolic diseases
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Research Articles

Loss of lysosomal membrane protein NCU-G1 in mice results in spontaneous liver fibrosis with accumulation of lipofuscin and iron in Kupffer cells
Xiang Y. Kong,Cecilie Kasi Nesset,Markus Damme,Else-Marit Løberg,Torben Lübke,Jan Mæhlen,Kristin B. Andersson,Petra I. Lorenzo,Norbert Roos,G. Hege Thoresen,Arild C. Rustan,Eili T. Kase,Winnie Eskild
View articletitled, Loss of lysosomal membrane protein NCU-G1 in mice results in spontaneous liver fibrosis with accumulation of lipofuscin and iron in Kupffer cells
Supplementary information
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Cellular characterization of ultrasound-stimulated microbubble radiation enhancement in a prostate cancer xenograft model
Azza A. Al-Mahrouki,Sara Iradji,William Tyler Tran,Gregory J. Czarnota
View articletitled, Cellular characterization of ultrasound-stimulated microbubble radiation enhancement in a prostate cancer xenograft model
Supplementary information
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Synaptic abnormalities in a Drosophila model of Alzheimer’s disease
Siddhita D. Mhatre,Vivek Satyasi,Mark Killen,Brie E. Paddock,Robert D. Moir,Aleister J. Saunders,Daniel R. Marenda
View articletitled, Synaptic abnormalities in a <em>Drosophila</em> model of Alzheimer’s disease
Supplementary information
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Resource Articles

Subcutaneous preconditioning increases invasion and metastatic dissemination in mouse colorectal cancer models
Patricia Alamo,Alberto Gallardo,Miguel A. Pavón,Isolda Casanova,Manuel Trias,Maria A. Mangues,Esther Vázquez,Antonio Villaverde,Ramon Mangues,Maria V. Céspedes
View articletitled, Subcutaneous preconditioning increases invasion and metastatic dissemination in mouse colorectal cancer models
Supplementary information
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Early motor deficits in mouse disease models are reliably uncovered using an automated home-cage wheel-running system: a cross-laboratory validation
Silvia Mandillo,Ines Heise,Luciana Garbugino,Glauco P. Tocchini-Valentini,Alessandro Giuliani,Sara Wells,Patrick M. Nolan
View articletitled, Early motor deficits in mouse disease models are reliably uncovered using an automated home-cage wheel-running system: a cross-laboratory validation
Supplementary information
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Correction

The expanding role of fish models in understanding non-alcoholic fatty liver disease
Yoichi Asaoka,Shuji Terai,Isao Sakaida,Hiroshi Nishina
View articletitled, The expanding role of fish models in understanding non-alcoholic fatty liver disease
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Accepted manuscripts
Identification of HDAC inhibitors as neutrophil recruitment modulators in zebrafish using a chemical library screen
Sijia Fan, Jinlong Jiang, Huan Zhang, Cuihong Wang, Shang Kong, Tingting Zhao, Ling Meng, Yang Liu, Jingjing Qin, Xiuqin Rong, Zhenting He, Qinke He, Ke He, Ketong Chen, Ling Lei, Xinyu Hai, Hong Nie, Chunguang Ren
Microenvironment-dependent growth of Sezary cells in humanized IL-15 mice
Jie Gao, Shumei Ren, Gabrielle Choonoo, Guoying Chen, Davor Frleta, Jun Zhong, Namita Gupta, Prachi Sharma, Adelekan Oyejide, Gurinder S. Atwal, Lynn Macdonald, Andrew Murphy, Frank Kuhnert
Short tandem repeat profiling via next generation sequencing for cell line authentication
Yi-Hsien Chen, Jon P. Connelly, Colin Florian, Xiaoxia Cui, Shondra M. Pruett-Miller
Using Drosophila to model a variant of unknown significance in the human cardiogenic gene Nkx2.5
TyAnna L. Lovato, Brenna Blotz, Cayleen Bileckyj, Christopher A. Johnston, Richard M. Cripps
Comparative multi-omics analyses of cardiac mitochondrial stress in three mouse models of frataxin deficiency
Nicole M. Sayles, Jill S. Napierala, Josef Anrather, Nadège Diedhiou, Jixue Li, Marek Napierala, Hélène Puccio, Giovanni Manfredi
More accepted manuscripts

DMM Journal Meeting 2024: Pre-clinical Modelling of Human Genetic Disease and Therapy

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Register your interest for our 2024 Journal Meeting.  Rapid advances in gene editing and genetic technologies have revolutionised our ability to model human genetic disease and provided new hope for gene therapies. At this Meeting, we will present the very latest advances in modelling human genetic disease. Find more information here.

A new call for papers is underway

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Showcase your latest research in our upcoming special issue Translating Multiscale Research in Rare Disease, coordinated by DMM Editors Monica Justice, Karen Liu and Monkol Lek, and Guest Editor Kate Rauen. The deadline for submitting articles to the special issue is Monday 6 November 2023.

Moving towards heart success – Disease Models & Mechanisms Special Issue

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DMM's most recent special issue compiles articles that aim to move heart failure to heart success by fundamentally addressing the roots of failure to identify curative strategies.

Adult zebrafish as advanced models of human disease

Adult zebrafish 

Editor-in-Chief Liz Patton and Editorial Board member Rich White discuss the unique advantages of adult zebrafish for studying human disease biology. Read the Open Access Editorial here.

The Forest of Biologists

 

The Forest of Biologists is a biodiversity initiative created by The Company of Biologists, with support from the Woodland Trust. For every Research and Review article published in Disease Models & Mechanisms a native tree is planted in a UK forest. In addition to this we are protecting and restoring ancient woodland and are dedicating these trees to our peer reviewers. Visit our virtual forest to learn more.

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