Issues
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Cover image
Cover Image
Cover: Staining for DNA damage in sections from prostate cancer xenograft tumours, showing immunostaining of γH2AX (red fluorescence) and overlay with DAPI as a counterstain (blue fluorescence). Strong labeling was seen with the different treatments, including with the combined treatment of ultrasound-stimulated microbubbles combined with high radiation (MB+US+8Gy), shown here. See article by Al-Mahrouki et al. on page 363. - PDF Icon PDF LinkTable of contents
In This Issue
Community News
A Model For Life
Revolutionizing cancer care with next-generation sequencing: an interview with Elaine Mardis
Elaine Mardis, co-director at the Washington University Genome Institute, has a long-standing interest in the development of sequencing technologies, which, in the 1990s, led her to play a pivotal role in the completion of the Human Genome project. Driven by the desire to apply her technological know-how to the improvement of human health, she then pioneered the sequencing and analysis of cancer genomes. These milestones have established Elaine as a leader in the cancer genomics field. In this interview, she recalls the events that shaped her career path, discusses the value of industry experience in a research setting, and provides her perspectives on challenges to clinical implementation of next-generation sequencing.
Reviews
Research Articles
Loss of lysosomal membrane protein NCU-G1 in mice results in spontaneous liver fibrosis with accumulation of lipofuscin and iron in Kupffer cells
Resource Articles
Correction
New Special Issue: Translating Multiscale Research in Rare Disease. Edited by Monica Justice, Monkol Lek, Karen Liu and Kate Rauen.
This special issue features original Research, Resources & Methods and Review-type articles that aim to interrogate the mechanisms of rare diseases to foster meaningful clinical progress in their diagnosis and treatment.
The role of the International Society for Stem Cell Research (ISSCR) guidelines in disease modelling
The ISSCR provides comprehensive guidelines and standards for using human stem cells in biomedical research. In this Editorial, Cody Juguilon and Joseph Wu discuss how and why these should be incorporated in disease modelling research.
Subject collection: Building advocacy into research
DMM’s series - Building advocacy into research - features interviews, ‘The Patient’s Voice’, with patients and advocates for a range of disease types, with the aim of supporting the highest quality research for the benefit of all patients affected by disease.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.
Biologists @ 100 - join us in Liverpool in March 2025
We are excited to invite you to a unique scientific conference, celebrating the 100-year anniversary of The Company of Biologists, and bringing together our different communities. The conference will incorporate the Spring Meetings of the BSCB and the BSDB, the JEB Symposium Sensory Perception in a Changing World and a DMM programme on antimicrobial resistance. Find out more and register your interest to join us in March 2025 in Liverpool, UK.