Issues
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Cover image
Cover Image
Cover: Immunocytochemistry image of an in vitro model of human neocortical development using human pluripotent stem cells. Neocortical neurons are immunostained to show TUJ1 (green) and proliferating progenitor cells are immunostained to show Ki67 (red). Structures that retain essential features of human neocortical development formed after neuroepithelial rosettes were seeded and cultured in the presence of neocortical trophic factors. This model is amenable to drug screening and can be employed to identify strategies for preventing or ameliorating conditions of developmental injury to the human cerebral cortex. See article by Kindberg et al. on page 1397.Close Modal - PDF Icon PDF LinkTable of contents
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IN THIS ISSUE
A MODEL FOR LIFE
‘Back and forth’ from models to patients to understand kidney disease: an interview with Katalin Susztak
Katalin Susztak is currently Associate Professor at Perelman School of Medicine at the University of Pennsylvania, where she conducts research on chronic and diabetic kidney disease. After her medical studies, her science career began by investigating ion-channel regulation and function at Semmelweis University, in Budapest. She then moved to the United States, where, thanks to the fortunate encounter with her future mentor, Erwin Böttinger, she worked as a research fellow in the Renal Division of the Albert Einstein College of Medicine in New York. Since then, she has successfully kept pursuing her career in the field of kidney research. The innovative approach of Katalin’s lab is to combine efficient high-throughput analysis of patient samples with mechanistic approaches in animal models, in order to advance our understanding of kidney disease mechanisms and identify new therapeutic targets. In this interview, Katalin travels through her career, from her first steps into biophysics, to her residency and finally to her established position as a kidney-specialist scientist, discussing exciting aspects of her work and current challenges in her field.
REVIEW
RESEARCH ARTICLES
Triptolide treatment reduces Alzheimer’s disease (AD)-like pathology through inhibition of BACE1 in a transgenic mouse model of AD
RESOURCE ARTICLES
Call for papers: Moving Heart Failure to Heart Success

Disease Models & Mechanisms is pleased to welcome submissions for consideration for an upcoming special issue, Moving Heart Failure to Heart Success: Mechanisms, Regeneration & Therapy. The deadline for submitting articles to the special issue has been extended to 1 August 2022.
Modelling interactions at the blood–brain barrier

In their Review, Yvonne Adams and Anja Ramstedt Jensen review the available in vitro models to investigate the impact of adhesion of Plasmodium falciparum-infected red blood cells on the blood–brain barrier, a process associated with cerebral malaria.
Call for new preLighters

preLights is the preprint highlighting community supported by The Company of Biologists. At the heart of preLights are our preLighters: early-career researchers who select and write about interesting new preprints for the research community. We are currently looking for new preLighters to join our team. Find out more and apply here.
Focus on Genetic Variance in Human Disease

New technologies, computational methods and model systems are revealing how human genetic variance contributes to disease mechanisms. DMM’s new Subject Focus highlights this evolving area of research.
Apply for a DMM Conference Travel Grant

Aimed at early-career researchers wanting to attend in-person and virtual meetings, the next application deadline for a DMM Conference Travel Grant is 1 September 2022. Find out more and hear from past recipients about their experience of the grant.