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Cover: Macro image of an individual Drosophila melanogaster used for in vivo high-throughput screening in myotonic dystrophy type 1 (DM1). This fly model does not display eye-observable disease phenotypes but combines simultaneous expression of the disease-causing mutation and a luciferase-reporter system, which allows the reliable quantification of a DM1-linked differential splicing event (spliceosensor flies). These reporter-based flies launched a novel in vivo drug-discovery assay from well-established in vitro approaches, and allowed fast large-scale chemical screening using Drosophila melanogaster. Image kindly provided by Dr Arturo López Castel. See article by García-Alcover et al. on page 1297.Close Modal - PDF Icon PDF LinkTable of contents
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Virtual Meeting - Developmental Disorders: From Mechanism to Treatment
A collaboration between the Development and Disease Models & Mechanisms journal teams, this virtual Meeting will unite developmental biologists, human geneticists and clinical researchers to focus on building bridges from bench to clinic. Register your interest and find out more.
High-dose vitamin B1 therapy prevents the development of experimental fatty liver driven by overnutrition
Vitamin B1 is shown to prevent nutrition-induced fatty liver in our current Editor’s choice by Hay Davir and his colleagues, when they use sheep as a large-animal model for studying the disease.
Find out more in an interview with the paper's first authors, Mugagga Kalyesubula and Ramgopal Mopuri.
Upcoming grant deadlines
Call for papers - The RAS Pathway: Diseases, Therapeutics and Beyond
Our upcoming special issue is welcoming submissions until 3 May 2021. Guest-edited by Donita Brady (Perelman School of Medicine at the University of Pennsylvania, USA) and Arvin Dar (Icahn School of Medicine at Mount Sinai, USA), the issue will focus on targeting the RAS pathway.
