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Volume 7, Issue 10

October 2014

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Cover image

Cover Image

Cover: Mirrored image of a primary human fetal dopaminergic cell in the striatum of a rat brain. The cell had been coated ex vivo with a surrogate stroma of nanoparticles containing growth factor to support survival and maturation in vivo, modelling cell therapy for Parkinson’s disease. Image kindly provided by Dr Delisa Garcia using Imaris Filament Tracer software: colours relate to the dimensions of neurites and cell body. See article by Zhao et al. on page 1193.
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Issue info

ISSN 1754-8403

EISSN 1754-8411

In this issue

IN THIS ISSUE
REVIEW
RESEARCH ARTICLES
RESOURCE ARTICLE

IN THIS ISSUE

Therapeutic stromal nanoparticles for Parkinson’s disease

Extract

View articletitled, Therapeutic stromal nanoparticles for Parkinson’s disease

Advancing congenital defect phenotyping using HREM imaging

Extract

View articletitled, Advancing congenital defect phenotyping using HREM imaging

REVIEW

Microbial imbalance and intestinal pathologies: connections and contributions

Ye Yang,Christian Jobin

Abstract

View articletitled, Microbial imbalance and intestinal pathologies: connections and contributions

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RESEARCH ARTICLES

Phenotyping structural abnormalities in mouse embryos using high-resolution episcopic microscopy

Wolfgang J. Weninger,Stefan H. Geyer,Alexandrine Martineau,Antonella Galli,David J. Adams,Robert Wilson,Timothy J. Mohun

Abstract

View articletitled, Phenotyping structural abnormalities in mouse embryos using high-resolution episcopic microscopy

Supplementary information

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Genetic interactions between planar cell polarity genes cause diverse neural tube defects in mice

Jennifer N. Murdoch,Christine Damrau,Anju Paudyal,Debora Bogani,Sara Wells,Nicholas D. E. Greene,Philip Stanier,Andrew J. Copp

Abstract

View articletitled, Genetic interactions between planar cell polarity genes cause diverse neural tube defects in mice

Supplementary information

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A Drosophila model of mitochondrial disease caused by a complex I mutation that uncouples proton pumping from electron transfer

Jonathon L. Burman,Leslie S. Itsara,Ernst-Bernhard Kayser,Wichit Suthammarak,Adrienne M. Wang,Matt Kaeberlein,Margaret M. Sedensky,Philip G. Morgan,Leo J. Pallanck

Abstract

View articletitled, A <em>Drosophila</em> model of mitochondrial disease caused by a complex I mutation that uncouples proton pumping from electron transfer

Supplementary information

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Potentiated Hsp104 variants suppress toxicity of diverse neurodegenerative disease-linked proteins

Meredith E. Jackrel,James Shorter

Abstract

View articletitled, Potentiated Hsp104 variants suppress toxicity of diverse neurodegenerative disease-linked proteins

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Isolating the role of elevated Phlda2 in asymmetric late fetal growth restriction in mice

Simon J. Tunster,Mathew Van De Pette,Rosalind M. John

Abstract

View articletitled, Isolating the role of elevated <em>Phlda2</em> in asymmetric late fetal growth restriction in mice

Supplementary information

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RESOURCE ARTICLE

Modelling of a targeted nanotherapeutic ‘stroma’ to deliver the cytokine LIF, or XAV939, a potent inhibitor of Wnt–β-catenin signalling, for use in human fetal dopaminergic grafts in Parkinson’s disease

Jing-Wei Zhao,Sean C. Dyson,Christina Kriegel,Pam Tyers,Xiaoling He,Tarek M. Fahmy,Su M. Metcalfe,Roger A. Barker

Abstract

View articletitled, Modelling of a targeted nanotherapeutic ‘stroma’ to deliver the cytokine LIF, or XAV939, a potent inhibitor of Wnt–β-catenin signalling, for use in human fetal dopaminergic grafts in Parkinson’s disease

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Accepted manuscripts

Microvascular aberrations found in human polycystic kidneys are an early feature in a Pkd1 mutant mouse model

Daniyal J. Jafree, Charith Perera, Mary Ball, Daniele Tolomeo, Gideon Pomeranz, Laura Wilson, Benjamin Davis, William J. Mason, Eva Maria Funk, Maria Kolatsi-Joannou, Radu Polschi, Saif Malik, Benjamin J. Stewart, Karen L. Price, Hannah Mitchell, Reza Motallebzadeh, Yoshiharu Muto, Robert Lees, Sarah Needham, Dale Moulding, Jennie C. Chandler, Sonal Nandanwar, Claire L. Walsh, Paul J. D. Winyard, Peter J. Scambler, René Hägerling, Menna R. Clatworthy, Benjamin D. Humphreys, Mark F. Lythgoe, Simon Walker-Samuel, Adrian S. Woolf, David A. Long

CIB2 function is distinct from Whirlin in the development of cochlear stereocilia staircase pattern

Arnaud P. J. Giese, Andrew Parker, Sakina Rehman, Steve D. M. Brown, Saima Riazuddin, Craig W. Vander Kooi, Michael R. Bowl, Zubair M. Ahmed

Reduced growth and biofilm formation at high temperatures contribute to Cryptococcus deneoformans dermatotropism

Claudia L. Charles-Nino, Gunjan M. Desai, Nicholas Koroneos, Mohamed F. Hamed, Neena Jain, William Lopes, Anthony Braswell, Alexander Linares, Melissa E. Munzen, Joshua D. Nosanchuk, Marilene H. Vainstein, Luis R. Martinez

Mutations in the Bone Morphogenetic Protein signaling pathway sensitize zebrafish and humans to ethanol-induced jaw malformations

John R. Klem, Tae-Hwi Schwantes-An, Marco Abreu, Michael Suttie, Raeden Gray, Hieu Vo, Grace Conley, Tatiana M. Foroud, Leah Wetherill, CIFASD, C. Ben Lovely

Robust behavioral assessment of the inducible Friedreich's ataxia mouse does not show improvement with NRF2 induction

Claire B. Montgomery, Lili Salinas, Garrett P. Cox, Lauren E. Adcock, Tiffany Chang, Francisco Figueroa, Gino Cortopassi, Elena N. Dedkova

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