Issues
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Cover image
Cover Image
Cover: Kinetic stabilisation of tetrameric transthyretin by binding of the drug Tafamidis (Vyndaqelª) in the T4-binding sites, inhibiting amyloidogenesis. PDB accession code: 3TCT. Image courtesy of Drs Stephen Connelly, Evan Powers, Ian Wilson and Jeff Kelly, The Scripps Research Institute, CA, USA. - PDF Icon PDF LinkTable of contents
IN THIS ISSUE
EDITORIAL
A MODEL FOR LIFE
Creating a path from the heat shock response to therapeutics of protein-folding diseases: an interview with Rick Morimoto
Rick Morimoto Director of the Rice Institute of Biomedical Research and the Bill and Gayle Cook Professor of Biology at Northwestern University, is renowned for his insights into the heat shock response and its role in protein-folding diseases and aging. As part of Disease Models & Mechanisms’ (DMM’s) special series on protein-folding diseases, Rick recalls the karmic events that influenced his career and discusses the importance of invertebrate model systems to reveal the basic mechanisms underlying aging and protein misfolding, as well as efforts to discover therapies to reverse these biological processes.
AT A GLANCE
REVIEWS
RESEARCH ARTICLES
Valproic acid silencing of ascl1b/Ascl1 results in the failure of serotonergic differentiation in a zebrafish model of fetal valproate syndrome
A missense mutation accelerating the gating of the lysosomal Cl−/H+-exchanger ClC-7/Ostm1 causes osteopetrosis with gingival hamartomas in cattle
Oleoylethanolamide enhances β-adrenergic-mediated thermogenesis and white-to-brown adipocyte phenotype in epididymal white adipose tissue in rat
RESEARCH REPORTS
Inhibitors of neutrophil recruitment identified using transgenic zebrafish to screen a natural product library
Call for papers – In Vitro Models of Human Disease to Inform Mechanism and Drug Discovery
We invite you to submit your latest research to our upcoming special issue: In Vitro Models of Human Disease to Inform Mechanism and Drug Discovery, coordinated by DMM Editor Vivian Li (The Francis Crick Institute, London, UK), alongside Guest Editors Austin Smith (University of Exeter, UK) and Joseph Wu (Stanford University School of Medicine, USA).The deadline for submitting articles is 6 October 2025.
The Company of Biologists Workshops
For the last 15 years, our publisher, The Company of Biologists, has provided an apt environment to inspire biology and support biologists through our Workshops series. Read about the evolution of the Workshop series and revisit JEB's experience with hosting the first Global South Workshop.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.
Fast & Fair peer review
Our sister journal Biology Open has recently launched the next phase of their Fast & Fair peer review initiative: offering high-quality peer review within 7 working days. To learn more about BiO’s progress and future plans, read the Editorial by Daniel Gorelick, or visit the Fast & Fair peer review page.
Propose a new Workshop for 2027
We are currently seeking proposals for Workshops to be held in 2027. As one of the scientific organisers of a The Company of Biologists Workshop, your involvement will be focused on interdisciplinary, cutting-edge science and promoting new partnerships and collaborations. We focus on the logistics. Are you thinking about proposing a topic for one of our Workshops? Apply by Friday 30 May 2025.
