IN THIS ISSUE
A MODEL FOR LIFE
Creating a path from the heat shock response to therapeutics of protein-folding diseases: an interview with Rick Morimoto
Rick Morimoto Director of the Rice Institute of Biomedical Research and the Bill and Gayle Cook Professor of Biology at Northwestern University, is renowned for his insights into the heat shock response and its role in protein-folding diseases and aging. As part of Disease Models & Mechanisms’ (DMM’s) special series on protein-folding diseases, Rick recalls the karmic events that influenced his career and discusses the importance of invertebrate model systems to reveal the basic mechanisms underlying aging and protein misfolding, as well as efforts to discover therapies to reverse these biological processes.