Issues
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Cover image
Cover Image
Cover: Immunofluorescent confocal microscopy of a 3-week-old mouse tibial growth plate and adjoining secondary centre of ossification. The section is stained to show the distribution of two important cartilage structural proteins: matrilin-3 (green) and type XII collagen (orange). The highly ordered chondrocyte ‘columns’ are clearly visible (nuclei stained blue with DAPI) with a matrilin-3-rich pericellular matrix appearing as a green halo around each cell. Type XII collagen is localised to the inter-territorial matrix between individual chondrocyte columns and at the border of the secondary centre of ossification. As professional secretory cells, chondrocytes are highly susceptible to ER stress due to the misfolding of mutant proteins in genetic skeletal diseases. See article by Gualeni et al. on page 1414. - PDF Icon PDF LinkTable of contents
In This Issue
Community News
Building bridges with zebrafish: highlights of the ‘Zebrafish Models in Translational Medicine’ meeting
Inspired by the growing prominence of the zebrafish model in biomedical research, EuFishBioMed (www.eufishbiomed.kit.edu/) and ZF-HEALTH (zf-health.org/) recently joined forces to organise a meeting with the primary aim of forging collaborations between the established ‘zebrafish community’ and newcomers that hope the model will shed light on unanswered questions in their disease area. The 3-day meeting, ‘Zebrafish Models in Translational Medicine’, which was co-sponsored by Disease Models & Mechanisms (DMM), was held in a small town in the outskirts of Paris (Gif-sur-Yvette). With no more than 100 participants, opportunities for networking were plentiful.
A Model For Life
Using zebrafish to shed light on melanoma: an interview with Liz Patton
Liz Patton is a Senior Lecturer at the MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, where she leads a research group whose goal is to understand melanocyte and melanoma development. Early on in her research career, Liz investigated cell cycle regulation in yeast and the implications for cancer, but now primarily exploits the zebrafish model to identify new pathways and therapeutic compounds relevant to melanoma. In this interview, Liz recalls some of her most exciting breakthroughs to date, discusses the advantages of zebrafish as a disease model and provides her perspectives on the current challenges in cancer research.
At A Glance
Special Article
Reviews
Research Articles
Sestrin-2, a repressor of PDGFRβ signalling, promotes cigarette-smoke-induced pulmonary emphysema in mice and is upregulated in individuals with COPD
A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide
Research Report
Resource Articles
DMM Journal Meeting 2024: Pre-clinical Modelling of Human Genetic Disease and Therapy

Registration is now open for our 2024 Journal Meeting. Rapid advances in gene editing and genetic technologies have revolutionised our ability to model human genetic disease and provided new hope for gene therapies. At this Meeting, we will present the very latest advances in modelling human genetic disease.
Moving towards heart success – Disease Models & Mechanisms Special Issue

DMM's most recent special issue compiles articles that aim to move heart failure to heart success by fundamentally addressing the roots of failure to identify curative strategies.
Crossroads in Virology

Our October Editorial written by Sumana Sanyal emphasises the urgency of a concerted effort in understanding virus–host interactions to inform the development of therapeutics and vaccines, helping to predict disease outcomes. Read the full Editorial here.
A Model for Life - an interview with Professor Kiran Musunuru




Read our new A Model for Life interview with Kiran Musunuru. Prof Musunuru investigates the mechanisms of disease in model systems, with the ultimate goal of developing innovative gene editing therapies.
Sustainable Conferencing Initiative

Through our Sustainable Conferencing Grants, we promote the use of new technology and greener modes of travel. Our blog posts showcase examples of sustainability in action and share experience about how new technologies and conference formats work in practice.