Issues
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Cover image
Cover Image
Cover: Immunofluorescent confocal microscopy of a 3-week-old mouse tibial growth plate and adjoining secondary centre of ossification. The section is stained to show the distribution of two important cartilage structural proteins: matrilin-3 (green) and type XII collagen (orange). The highly ordered chondrocyte ‘columns’ are clearly visible (nuclei stained blue with DAPI) with a matrilin-3-rich pericellular matrix appearing as a green halo around each cell. Type XII collagen is localised to the inter-territorial matrix between individual chondrocyte columns and at the border of the secondary centre of ossification. As professional secretory cells, chondrocytes are highly susceptible to ER stress due to the misfolding of mutant proteins in genetic skeletal diseases. See article by Gualeni et al. on page 1414. - PDF Icon PDF LinkTable of contents
In This Issue
Community News
Building bridges with zebrafish: highlights of the ‘Zebrafish Models in Translational Medicine’ meeting
Inspired by the growing prominence of the zebrafish model in biomedical research, EuFishBioMed (www.eufishbiomed.kit.edu/) and ZF-HEALTH (zf-health.org/) recently joined forces to organise a meeting with the primary aim of forging collaborations between the established ‘zebrafish community’ and newcomers that hope the model will shed light on unanswered questions in their disease area. The 3-day meeting, ‘Zebrafish Models in Translational Medicine’, which was co-sponsored by Disease Models & Mechanisms (DMM), was held in a small town in the outskirts of Paris (Gif-sur-Yvette). With no more than 100 participants, opportunities for networking were plentiful.
A Model For Life
Using zebrafish to shed light on melanoma: an interview with Liz Patton
Liz Patton is a Senior Lecturer at the MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, where she leads a research group whose goal is to understand melanocyte and melanoma development. Early on in her research career, Liz investigated cell cycle regulation in yeast and the implications for cancer, but now primarily exploits the zebrafish model to identify new pathways and therapeutic compounds relevant to melanoma. In this interview, Liz recalls some of her most exciting breakthroughs to date, discusses the advantages of zebrafish as a disease model and provides her perspectives on the current challenges in cancer research.
At A Glance
Special Article
Reviews
Research Articles
Sestrin-2, a repressor of PDGFRβ signalling, promotes cigarette-smoke-induced pulmonary emphysema in mice and is upregulated in individuals with COPD
A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide
Research Report
Resource Articles
Call for papers – In Vitro Models of Human Disease to Inform Mechanism and Drug Discovery
We invite you to submit your latest research to our upcoming special issue: In Vitro Models of Human Disease to Inform Mechanism and Drug Discovery, coordinated by DMM Editor Vivian Li (The Francis Crick Institute, London, UK), alongside Guest Editors Austin Smith (University of Exeter, UK) and Joseph Wu (Stanford University School of Medicine, USA).The deadline for submitting articles is 6 October 2025.
The Company of Biologists Workshops
For the last 15 years, our publisher, The Company of Biologists, has provided an apt environment to inspire biology and support biologists through our Workshops series. Read about the evolution of the Workshop series and revisit JEB's experience with hosting the first Global South Workshop.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.
Fast & Fair peer review
Our sister journal Biology Open has recently launched the next phase of their Fast & Fair peer review initiative: offering high-quality peer review within 7 working days. To learn more about BiO’s progress and future plans, read the Editorial by Daniel Gorelick, or visit the Fast & Fair peer review page.
A new perspective on disease research
DMM publishes perspectives - peer-reviewed articles that provide expert analysis of a topic important to the disease research community. Read our collection from authors presenting new or potentially controversial ideas or hypotheses, to help address future challenges and forge new directions.
