Issues
-
Cover image
Cover Image
![issue cover]()
Cover: Mutant mice with specific deletion of Ilk in neural crest cells show aortic aneurysms and a highly dilated common arterial trunk, which results in embryonic lethality during late gestation. Control (left) and Ilk conditional mutant (right) hearts from E12.5 embryos stained for X-gal. See article by Arnold et al. on page 1205.Close Modal - PDF Icon PDF LinkTable of contents
In This Issue
A Model For Life
A gutsy approach to stem cells and signalling: an interview with Hans Clevers
Hans Clevers, Professor of Molecular Genetics at Utrecht University, began his career in immunology and developmental biology, but a shift towards intestinal research in the late 1990s led to his group’s pioneering discovery that Lgr5 is a marker of tissue stem cells – a finding that paved the way for a cascade of key insights into the molecular signalling pathways that are dysregulated in cancer. Interviewed here by Ross Cagan, Editor-in-Chief of Disease Models & Mechanisms, Hans recalls the mentors and discoveries that motivated his transition from basic to applied science, discusses his style of lab management and mentorship, and highlights the potential of organoid-based therapy for personalised medicine.
Reviews
Podcast
Research Articles
Dmdmdx/Largemyd: a new mouse model of neuromuscular diseases useful for studying physiopathological mechanisms and testing therapies
Endogenous progesterone levels and frontotemporal dementia: modulation of TDP-43 and Tau levels in vitro and treatment of the A315T TARDBP mouse model
Research Reports
Resource Article
DMM Outstanding Paper Prize
"I am honored to receive the DMM 2020 Prize! This project had more than the average number of trials and tribulations, which is saying a lot, and now I know it was all worth it!"
Congratulations to Sarah Colijn, winner of the DMM Outstanding Paper Prize 2020. Sarah’s work challenges research regarding atherosclerosis and necroptosis to rethink the role of RIPK3.
An Fgfr3-activating mutation in immature murine osteoblasts affects the appendicular and craniofacial skeleton
In this month’s Editor’s Choice, Laurence Legeai-Mallet and colleagues show how Fgfr3 hyperactivation affects immature osteoblasts, contributing to the bone modifications observed in achondroplasia.
Life after a Travelling Fellowship
Ahead of the upcoming application deadline for a Travelling Fellowship on 31 May, Sina Krokowski talks about the ongoing impact of her trip in 2015, when she visited the Carballido-López lab in Paris to learn a technique that was vital for her PhD.
The DMM Conference Travel Grant deadline is also fast approaching. Apply for a grant to attend an event, virtual or otherwise, by 17 May.
Virtual Meeting - Developmental Disorders: From Mechanism to Treatment
A collaboration between the Development and Disease Models & Mechanisms journal teams, this virtual Meeting will unite developmental biologists, human geneticists and clinical researchers to focus on building bridges from bench to clinic. Register your interest and find out more.
Automated in vivo drug screen in zebrafish identifies synapse-stabilising drugs with relevance to spinal muscular atrophy
New work from the Becker Lab at the University of Edinburgh details an automated and high-throughput screening platform to identify compounds relevant to motor neuron disease using younger, less-pigmented zebrafish embryos.
